Jecho Laboratories Inc.

Jecho Institute, Co., Ltd.

Shanghai Jiao Tong University

Jecho Biopharmaceuticals Co Ltd.

Yueqing Xie

Lei Zhang

Jing Wang

Hua Jiang

Lei Han

Junsheng Chen

Huili Lu

Jianwei Zhu

Kai Ding

Huifang Zong

Baohong Zhang

A polypeptide composition, and methods of making the same, may include a first polypeptide and a second polypeptide, wherein the first polypeptide comprise a first toxin fragment and a first intein fragment, the second polypeptide comprise a second toxin fragment and a second intein fragment, the first polypeptide is different from the second polypeptide; the first toxin fragment and the second toxin fragment are non-biotoxic; the first polypeptide and the second polypeptide may make the first toxin fragment and the second toxin fragment into biotoxic toxins by an interaction of the first intein fragment and the second intein fragment. Kits may include such first and second polypeptides, and such compositions and kits may be used in treating tumors.

Polypeptide composition

Provided is a polypeptide combination, a targeting component thereof comprising a shielding peptide, a cleavable part, an antigen-binding part and a first intein fragment, the shielding peptide and the antigen-binding part being connected by means of the cleavable part, and the antigen-binding part being directly or indirectly connected to the first intein fragment; a toxin component thereof comprises a second intein fragment and a toxin, and the second intein fragment is directly or indirectly connected to the toxin; the targeting component and the toxin component form an immunoconjugate by means of the interactive action between the first intein fragment and the second intein fragment; in the immunoconjugate, the shielding peptide and the antigen-binding part are connected by means of the cleavable part, and the antigen-binding part is connected to the toxin. Also provided are a preparation method and a pharmaceutical use for the polypeptide combination.

Polypeptide combination used for tumour immunotherapy, and preparation method therefor

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Shanghai, China

Yueqing Xie