The Hong Kong University of Science and Technology

Biotechnology Research Corporation Limited

Yueqing Hu

Nancy Yuk-Yu Ip

Fanny Chui-Fun Ip

Wen Cai Ye

Fanny Chui Fun Ip

Nancy Y Ip

Yifan Han

Sookja Kim Chung

Yung Hou Wong

Maurice Kwok Chung Ho

David Charles New

Xixin He

Haihong Pang

The present invention provides therapeutically active compounds and compositions as receptor antagonists and methods of use thereof. In one aspect, the compounds are useful in modulating pain, inflammation and acute phase reactions by inhibiting the PGE2 receptors including PGE2 EP1, EP2 and EP4 receptors.

Triterpenoid compounds and methods of use thereof

The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in treating central nervous system disorders by over-activation of NMDA and/or MC receptors. In one aspect, the present invention provides methods of enhancing brain's cognitive function and reducing neuronal cell death in mammals and humans.

Receptor modulators exhibiting neuroprotective and memory enhancing activities

A method of treating, preventing, or ameliorating a pathological condition associated with a melatonin receptor in a mammal by using a pharmaceutical composition containing a compound of formula (I) as a ligand interacting with the melatonin receptor, R, R, R, Rand Rare independently H, halo, alkyloxyl, alkyl or hydroxyl, provided that one of R, R, Rand Ris X&#x2014;(CH)&#x2014;R; Ris alkyl or arylalkyl; Ris H or alkyl; X is a bond, O, S, SO, SO, CO or NH; n=-; Ris alkenyl, substituted or unsubstituted aryl, NRR, or OR; Ris H, substituted or unsubstituted arylmethyl, or alkenyl; and Ris H or alkyl.

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Novel heterodimers of tetrahydroacridines and tetrahydroquinolinones are disclosed. The heterodimers are capable of acting as both acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists. The heterodimers may be used to improve cognitive defects via treatment or prevention in both humans and non-humans.

Heterodimers and methods of using them

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Hong Kong, China

Yueqing Hu