Beijing Scitech-mq Pharmaceuticals Limited

Yueming Sun

Qiang Zhang

Leifu Yang

Shannan Yu

Nanqiao Zheng

Hongbo Zhang

Hailong Yang

Zhongxiang Wang

Shouye Feng

Yansheng Liu

Likai Zhou

Chenming Hu

Zhanqiang Xu

Disclosed are a class of compounds as inhibitors of kinases such as TRK, c-MET, AXL, MER and/or VEGFR2, compositions and use thereof. In particular, disclosed are a class of compounds (as shown in formula (1)) or isomers, solvates, hydrates, pharmaceutically acceptable salts, and prodrugs thereof having strong inhibition activities for kinases such as TRK, c-MET, AXL, MER and/or VEGFR2, and pharmaceutical compositions comprising said compounds. Also disclosed is use of the compounds or pharmaceutical compositions in the preparation of a medicament for treating autoimmune diseases or cancers.

Substituted aromatic ring-linked dioxinoquinazolines and dioxinoquinolines as kinase inhibitors

The present invention relates to a dioxinoquinoline compound of formula (I) or a pharmaceutically acceptable salt thereof. The invention also provides a preparation method of the compound of formula (I) and a pharmaceutically acceptable salt thereof, as well as uses thereof as a drug, wherein the drug acting as a tyrosine kinase (i.e. VEGFR-2 and c-MET) inhibitor is used for treating disorders related to tyrosine kinase. 

Dioxinoquinoline compounds, preparation method and uses thereof

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Beijing, China

Yueming Sun