Neumora Therapeutics, Inc.

Blackthorn Therapeutics, Inc.

Blackthor Therapeutics, Ine.

Yuelu Liu

Parvez Ahammad

Humberto Andres Gonzalez Cabezas

Monika Sharma Mellem

William J Martin

Pablo Christian Gersberg

Matthew Edward Kollada

Qingzhu Gao

Systems and methods for utilizing machine learning to generate a trans-diagnostic classifier that is operative to concurrently diagnose a plurality of different mental health disorders using a single trans-diagnostic questionnaire that includes a plurality of questions (e.g., 17 questions). Machine learning techniques are used to process labeled training data to build statistical models that include trans-diagnostic item-level questions as features to create a screen to classify groups of subjects as either healthy or as possibly having a mental health disorder. A subset of questions is selected from the multiple self-administered mental health questionnaires and used to autonomously screen subjects across multiple mental health disorders without physician involvement, optionally remotely and repeatedly, in a short amount of time.

Machine learning-based diagnostic classifier

A system for evaluating mental health of patients includes a memory and a control system. The memory contains executable code storing instructions for performing a method. The control system is coupled to the memory and includes one or more processors. The control system is configured to execute the machine executable code to cause the control system to perform the method: A selection of answers associated with a patient is received. The selection of answers corresponds to each question in a series of questions from mental health questionnaires. Unprocessed MRI data are received. The unprocessed MRI data correspond to a set of MRI images of a biological structure associated with the patient. The unprocessed MRI data is processed to output a set of MRI features. Using a machine learning model, the selection of answers and the set of MRI features are processed to output a mental health indication of the patient.

System and method for identifying transdiagnostic features shared across mental health disorders

A system includes a display device, a user interface, a memory, and a control system. The memory contains machine readable medium including machine executable code storing instructions for performing a method. The control system is coupled to the memory, and includes one or more processors. The control system is configured to execute the machine executable code to cause the control system to display, on the display device, a series of questions from mental health questionnaires. The series of questions includes text and answers for each question. From the user interface, a selection of answers of each of the displayed series of questions is received from a patient. Using a Bayesian Decision List, the received selection of answers is processed to output an indication of mental health of the patient. The indication of mental health identifies a kappa opioid receptor antagonist to which the patient would likely be a higher responder.

Systems and methods for screening, diagnosing, and stratifying patients

Systems and methods for utilizing machine learning to generate a trans-diagnostic classifier that is operative to concurrently diagnose a plurality of different mental health disorders using a single trans-diagnostic questionnaire that includes a plurality of questions (e.g., 17 questions). Machine learning techniques are used to process labeled training data to build statistical models that include trans-diagnostic item-level questions as features to create a screen to classify groups of subjects as either healthy or as possibly having a mental health disorder. A subset of questions are selected from the multiple self-administered mental health questionnaires and used to autonomously screen subjects across multiple mental health disorders without physician involvement, optionally remotely and repeatedly, in a short amount of time.

The method for evaluating mental health of a patient includes displaying a series of inquiries from mental health questionnaires on a display device. Each inquiry of the series of inquiries includes text and a set of answers. A series of selections is received from a user interface. Each selection of the series of selections is representative of an answer of the set of answers for each corresponding inquiry in the series of inquiries. Unprocessed MRI data are received. The unprocessed MRI data correspond to a set of MRI images of a biological structure associated with a patient. Using a machine learning model, the series of selections and the unprocessed MRI data are processed. The series of selections being processed corresponds to the series of inquiries. A symptom severity indicator for a mental health category of the patient is outputted.

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South San Francisco, CA, United States of America

Yuelu Liu