Amgen Inc.

Schering Corporation

Lexicon Pharmaceuticals, Inc.

Yuelie Lu

Yue-Sheng Li

Colin V Gegg

Qi Huang

Benny C Askew

Chuan-Fa Liu

Derin C D'amico

Gordon Ng

Thomas Storz

Mark A Jarosinski

Renmao Liu

Celia Dominguez

Andrew Stewart Tasker

Guolin Cai

Wenxue Wu

Robert D Larsen

Gilbert M Rishton

Xiaogen Yang

Richard W Draper

Eugene John Vater

Weifeng Hu

Jennifer N Chau

Tj Li

Radha V Iyer

Shawn Eisenberg

Jason Guohua Chen

Anthony King

Jr Benny C Askew

Liu Chuan-Fa

The present invention relates to processes for preparing indoline derivatives, particularly 1-acetyl-6-amino-3,3-dimethyl-2,3-dihydroindole.

Method for the preparation of 1-acetyl-6-amino-3,3-dimethyl-2,3-dihydroindole

The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a univalent vehicle, including peptides conjugated to univalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.

Antagonists of the bradykinin B1 receptor

The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a multivalent vehicle, including peptides conjugated to multivalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.

Methods of preparing compounds of formula I are disclosed: 

Methods of preparing imidazole-based bicyclic compounds

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Process for preparing 3,3-dimethylindolines

Selected novel substituted indolizine-like compounds are effective for treatment of diseases, such as TNF-&#x3b1;, IL-1&#x3b2;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Substituted indolizine-like compounds and methods of use

A short practical commercial process for the efficient enantioselective synthesis of the non-steroidal antiestrogen of formula I or XIV

Enantioselective synthesis

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Belle Mead, NJ, United States of America

Yuelie Lu