Other

National Taiwan University

Joben Bio-medical Co., Ltd.

China Medical University

Well Shine Biotechnology Development Co., Ltd.

Kang Jian Biotech Corp., Ltd.

Academia Sinica

Taipei Medical University

Yueh-Hsiung Kuo

Yun-Lian Lin

Wenchang Chiang

Cheng-Pei Chung

Cheng-Hsiu Lin

Chun-Ching Shih

Bi-Fong Lin

Ching-jang Huang

Chin Hsu

Min-Nan Lai

Young-Ji Shiao

Yung-Hsiang Chen

Yung-Chi Cheng

Ming-Jai Su

Ning-Sun Yang

Hsiu-Mei Chiang

Kuo-Ching Wen

Ssu-Ching Wang

Chieh-Hsi Wu

Chun-Hsu Pan

Chen-Kung Chou

Chih-Wei Chou

Sheau-Farn Yeh

Yonglian Zhu

Chang-Syun Yang

Ching-jing Huang

Wei-Yi Cheng

Yi-Ming Chiang

Yong-Han Hong

Juliang Zhu

Shu-Yi Yin

Chin-Heng Yang

Lei Fu

A method for suppressing tumor metastasis, in which an effective amount of a compound of formula (I) is administered to a subject in need thereof. Also disclosed is a method of treating cancer, in which an effective amount of a chemotherapy agent and an effective amount of a compound of formula (I) is administered to a subject in need thereof. Further disclosed are pharmaceutical compositions for suppressing tumor metastasis and for treating cancer, each of the compositions containing a compound of formula (I).

Use of benzofuran lignans to induce IL-25 expression and suppress mammary tumor metastasis

The present invention develops a series of methyl caffeate derivatives having biological activity in anti-angiogenesis. The present invention suggests that the compounds of the invention possess inhibiting angiogenesis through regulation of VEGF/VEGFR-2 and its downstream signaling cascades in the vascular endothelial cells (VECs).

Caffeic acid derivatives for anti-angiogenesis

The present invention provides a method for treating type 1 diabetes, hyperlipidemia or hepatic lipid accumulation by using dehydroeburicoic acid, as well as a method for decreasing levels of blood glucose, plasma total cholesterol, and triglyceride, and increasing insulin levels; and a method for decreasing hepatic balloon degeneration; and increasing expression levels of membrane GLUT4 and phospho-Akt in myotubes; and enhancing expression levels of membrane glucose transporter 4 (GLUT4) in skeletal muscle, and phospho-AMPK in both skeletal muscle and liver tissue using dehydroeburicoic acid.

Use of dehydroeburicoic acid fromin the treatment or prevention of diabetes and hyperlipidemia

Provided is a method of treating metabolic diseases including type 2 diabetes, insulin resistance, hyperglycemia, hyperlipidemia, obesity, hepatic steatosis, and hyperinsulinemia in a subject in need, including the step of administering to the subject a therapeutically effective amount of antcin K. Also provided is a method of enhancing protein expression ratio of phospho-5' adenosine monophosphate-activated protein kinase (phospho-AMPK) to total AMPK in skeletal muscle or liver of a subject, and a method of reducing blood leptin in a subject. Antcin K exerts prominent antidiabetic and antihyperlipidemic effects through regulation of membrane GLUT4, AMPK, Akt PPAR&#x3b1;, FAS, and PPAR&#x3b3; protein expressions and G6Pase, DGAT2, SREBP-1c, aP2, apoCIII, SREBP2, and PPAR&#x3b1; mRNA expressions.

Method for treatment of hyperglycemia and hyperlipidemia

The present invention provides a method of treating or preventing hyperlipidemia in a subject in need thereof. Such method includes, specifically, administrating to the subject a therapeutically effective amount of a caffeamide derivative. The present invention also provides a pharmaceutical composition containing, primarily, the caffeamide derivative. The method and pharmaceutical composition of the present invention can effectively and significantly lower the high-fat diet-induced body weight gain and absolute visceral fat weight as well as the concentration of triglycerides and free fatty acids in blood, and levels of total lipid and triacylglycerol in liver tissue. In addition, the caffeamide of the present invention also reduces size of adipocyte, hepatocellular ballooning phenomenon, and liver steatosis. Through promotion of phosphorylation of 5' adenosine monophosphate-activated protein kinase (AMPK) in muscle and liver, the caffeamide derivatives of the present invention is suitable for ameliorating or remedying hyperlipidemia.

Method of treating or preventing hyperlipidemia with caffeamide derivatives

The present invention provides a method for treating diabetes, hyperlipidemia or hepatic total lipids by using ergostatrien-3&#x3b2;-ol and its derivatives, as well as a method for decreasing blood glucose and HbA1c levels and reducing blood total cholesterol and triglyceride levels, whereas increasing blood HDL-C levels; and a method for decreasing hepatic total lipid and triacylglycerol levels; and increasing expression levels of membrane glucose transporter 4 (GLUT4) and phospho-Akt in skeletal muscle tissue, and phospho-AMPK in both skeletal muscle and liver tissue using ergostatrien-3&#x3b2;-ol and its derivatives.

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The present invention provides a method for treating breast cancer in a subject, which comprises administering to said subject an effective amount of an alcohol extract of dehulled adlay seeds. Preferably, an ethyl acetate sub-fraction of the alcohol extract of dehulled adlay seeds has a better effect in treating breast cancer.

Alcohol extract of dehulled adlay seeds for treating breast cancer

A method for anti-skin aging, especially for anti-skin photo-aging in a subject is provided. The method comprising administering to the subject an effective amount of an active component selected from the group consisting of a caffeamide derivative of formula (I), a pharmaceutically acceptable salt of the caffeamide derivative, and a combination thereof: wherein A is H or an alkyl; B is &#x2014;[CH2]&#x2014;; m is an integer ranging from 0 to 10; R1 is H, an optionally substituted phenyl, an optionally substituted pyridyl, &#x2014;OH, or &#x2014;OCH; or, N, A, B, and R1 together form an optionally substituted pyrrolyl or piperidyl.

Method for anti-skin aging using caffeamide derivative

A method for preparing polysaccharide nanocomposite particles is provided. The method comprises providing a first solution comprising an active component and a polysaccharide; adding a cross-linking agent to the first solution to provide a second solution; and allowing the second solution to conduct the reaction to form polysaccharide nanocomposite particles. The polysaccharide nanocomposite particles thus prepared show good coating ratio and enhanced applicability. Also provided is a method for inducing cancer cell apoptosis in a subject, comprising administrating to the subject an effective amount of the polysaccharide nanocomposite particles.

Method for preparing polysaccharide nanocomposite particles and uses of the same

The present invention provides a method for treating gastric ulcer and/or stomach cancer in a subject, which comprises administering to said subject an effective amount of an alcohol extract of dehulled adlay seeds. Preferably, an ethyl acetate sub-fraction of the alcohol extract of dehulled adlay seeds has a better effect in treating gastric ulcer and/or stomach cancer.

Alcohol extract of dehulled adlay seeds for treating gastric ulcer and/or stomach cancer

Disclosed is a cucurbitane-triterpenoid compound for activating estrogen receptor activity, and a pharmaceutical composition, use and preparation method thereof. The cucurbitane-triterpenoid compound is presented as formula (I): wherein a single bond or a double bond is formed between C5 and C10, and a single bond or a double bond is fromed between C8 and C9; when a single bond is formed between C5 and C10, the Ris oxygen; while a single bond is formed between C8 and C9, Ris carbonyl group (&#x2014;C&#x2550;O), methyl hydroxyl group (&#x2014;CH(OH)), methyl ketone or methyl dimethoxy group (&#x2014;CH(OCH)); and wherein while Ris oxygen (&#x2014;O&#x2014;) and Ris carbonyl group (&#x2014;C&#x2550;O) or methyl hydroxyl group (&#x2014;CH(OH)), a single bond is formed between R(&#x2014;O&#x2014;) and C19 of Rsuch that Rand Rare formed tetrahydro-2H-pyran-2-one or hemiacetal ring.

Cucurbitane-triterpenoid compounds, pharmaceutical composition, use and preparation method thereof

Disclosed herein are isolated compounds or pharmaceutically acceptable salts thereof, which exhibit immunostimulatory or anti-inflammatory effects. The compounds are isolated from the fruiting body ofin a solid culture. Also disclosed are methods of stimulating immune responses and/or treating an inflammatory disorder with these compounds and pharmaceutical compositions including the compounds or pharmaceutically acceptable salts thereof.

The present invention provides novel spiroenones extracted from an alcohol extract of dehulled adlay seeds. The present invention also provides a process for the preparation of the spiroenones and a method for treating breast cancer in a subject, which method comprises administering to said subject an effective amount of the spiroenone and a pharmaceutically acceptable carrier or excipient.

Spiroenone and uses thereof

The present invention provides novel lactams extracted from an alcohol extract of dehulled adlay seeds. The present invention also provides a process for the preparation of the lactams and a method for treating breast cancer in a subject, which method comprises administering to said subject an effective amount of the lactam and a pharmaceutically acceptable carrier or excipient.

Lactams and uses thereof

Methods of stimulating immune response or treating an inflammatory disorder with one of a number of the compounds disclosed herein or a pharmaceutically acceptable salt thereof.

Growing community of inventors

Taipei, Taiwan

Yueh-Hsiung Kuo