Atomic Energy Council-Institute of Nuclear Energy Research

Yueh-Feng Deng

Cheng-Fang Hsu

Yu Lung Chang

Show-Wen Liu

Tsung-Hsien Chiang

Chih-Yuan Lin

Kuei-Lin Lu

Da-Ming Wang

Ching-Yun Li

Ming-Che Tsai

Ching-Yun Lee

A precursor used for labeling hepatocyte receptors and applied to radiotracers for imaging or pharmaceutical compositions for liver cancers is revealed. The precursor is a bifunctional compound. The bifunctional group includes a trisaccharide structure and a diamide dimercaptide (NS) ligand. The trisaccharide has high affinity to asialoglycoprotein receptors (ASGPR) on surfaces of hepatocytes while NSligand reacts with radioisotopes to form neutral complexes. Thus the precursor stays on surfaces of hepatocytes to provide radioisotope labeling or treatment effect of liver cancers.

Precursor used for labeling hepatorcyte receptor and containing trisaccharide and diamide demercaptide ligand, method for preparing the same, radiotracer and pharmaceutical composition of the same

A method for preparing a radiotracer precursor SnADAM is revealed. The method overcomes shortcomings of conventional synthesis methods including lower yield rate and time-consuming. Moreover, Pd/C catalyst and hydrogen gas are used to catalyze reduction reaction for avoiding the generation of a large amount of intermediate products with similar structures. Thus there is no need to perform isolation and purification processes. The yield rate of the intermediate products is also increased so that its impact on the low yield rate of the final product SnADAM is minimized. A part of the reaction is significantly accelerated by using tris(dibenzylideneacetone)-dipalladium(0) (Pd(dba)) as a catalyst. Thus the production time of SnADAM is shortened.

Method for preparing radiotracer precursor SnADAM

A precursor SnBZM for a dopamine receptor radiotracer and a method for preparing the same are revealed. The precursor includes a tributyltin group (BuSn) that is easy to be replaced. Thus a dopamine receptor radiotracerI-IBZM can be produced at high yield rate by a substitution reaction of the precursor. At the same time, both the method for preparing the precursor SnBZM and a method for preparing a reference standard IBZM are simplified. Moreover, stability of each product is improved.

Radiotracer precursor and method for preparing the same

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Taoyuan County, Taiwan

Yueh-Feng Deng