Huntsman International LLC

Fudan University

Shanghai Bajiayi Pharmaceutical Science and Technology Co. Ltd.

Yuefan Zhang

Lies Bonami

Tiejun Li

Fan Xie

Yaocheng Rui

Pengfei Wu

Joris Karel Peter Bosman

Hao Cheng

Qiming Xu

Ingrid Welvaert

Joris Bosman

Pengyuan Yang

Xuerong Zhu

Zuxia Rong

Jie Pan

Bao Luan

Xiangshi Tan

Zhenghe Zhang

Hualiang Zhong

This disclosure generally provides tris (hydroxymethyl) phosphine oxide based polyfunctional polyester polyol compounds and resin compositions made therefrom which have improved flammability, wherein the resin composition comprising: (a) a polyfunctional isocyanate; (b) an isocyanate reactive composition comprising (b1) a polyfunctional polyol composition and a catalyst composition; and optionally (b2) a polyfunctional amine; wherein the polyfunctional polyol composition comprises tris (hydroxymethyl) phosphine oxide based polyfunctional polyester polyol compound.

Tris (hydroxymethyl) phosphine oxide based polyester polyol and a resin composition obtained therefrom

This disclosure generally provides compositions with improved flammability resistance and processes for preparing these compositions, wherein the resin composition comprising: (a) a polyfunctional isocyanate; (b) an isocyanate reactive composition comprising (b1) a polyfunctional polyol and a catalyst composition; and/or (b2) a polyfunctional amine; and (c) a benzoxazine component solved in the resin composition.

Benzoxazine based polyurethane resin composition

Disclosed is a reaction mixture for the manufacturing of a polyurethane foam, which mixture can be obtained by reacting a polyfunctional isocyanate with an isocyanate-reactive compound, in the presence of a scavenger and at least one catalyst; and curing such reaction mixture enables providing a foam with reduced aldehyde emissions particularly useful in means of transport, such as interior part of cars.

Reaction mixture suitable for manufacturing of foam with reduced aldehyde emission

This invention generally provides composition for making a polyurethane foam with reduced aldehyde emission and more specially to composition useful in means of transport such as interior part of cars, wherein composition is comprising: (a) a polyfunctional isocyanate; (b) an isocyanate reactive composition; and (c) a compound of the formula (I) or (II), wherein the compound (c) is present by weight percentage in the composition in an amount ranging from about 0.001 to about 10, preferably from about 0.01 to about 5, and more preferably from about 0.05 to about 2 based on the total weight of the composition. The compositions can reduce aldehyde emission, especially acetaldehyde emission in the PU foam and has no obvious influence on the mechanic properties of the foam.

Composition with reduced aldehyde emission

The present invention belongs to the field of medicine technology, particularly relating to an application of cyclic dinucleotide (cGAMP) in tumor treatment. Researches carried out in the present invention show that, cGAMP can inhibit growth of many types of tumor cells, with remarkable anti-tumor effect, thus, it can be used in preparation of anti-tumor drugs; and the prepared anti-tumor drugs have low toxicity and favorable effect. Proved by a subcutaneous tumor model in nude mice, cGAMP has a remarkable inhibition effect on tumors of human gastric carcinoma cell line MNK-45, human lung adenocarcinoma cell line A549, human colorectal carcinoma cell line Lovo, human hepatocellular carcinoma cell line SMMC-7721, human prostatic carcinoma cell line PC-3 and human pancreatic carcinoma cell SW1990, which are subcutaneously implanted in nude mice, and also proved by animal acute toxicity experiment. cGAMP has a relatively low acute toxicity, therefore and may be used for preparing anti-tumor drugs.

Application of cyclic dinucleotide (cGAMP) in anti-tumor field

Use of polypeptide micromolecule MLIF in preparing medicine for preventing and treating myocardial ischmia, where amino acid sequence of the polypeptide micromolecule MLIF is Met-Gln-Cys-Asn-Ser (SEQ ID NO:1).

Method for treating myocardial ischemia

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Shanghai, China

Yuefan Zhang