Zymogenetics, Inc.

Octadem Technologies, Inc.

Yue Yao

Janine M Bilsborough

Scott R Presnell

Debra G Gilbertson

Pallavur V Sivakumar

Eugene C Yi

George Robert Mabry, Iii

Marshall D Snavely

Julia E Novak

Wenfeng Xu

Fan He

Emma E Moore

Catherine E Lofton-Day

Cecile Krejsa

Randal Henne

Karen L Madden

Linda Zuckerman

Zhihao Lin

Mark Rogge

George R Mabry

Kevin P Foley

Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.

Use of IL-31 monoclonal antibodies for treating neuronal inflammation

Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include soluble receptors, antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.

Use of IL-31RA monoclonal antibodies for treating neuronal inflammation

Disclosed are antagonists of PDGF receptor &#x3b2; (PDGFR&#x3b2;) and VEGF-A, including neutralizing anti-PDGFR&#x3b2; and anti-VEGF-A antibodies, as well as related compositions and methods. Anti-PDGFR&#x3b2; and anti-VEGF-A antibodies disclosed herein include bispecific antibodies capable of binding and neutralizing both PDGFR&#x3b2; and VEGF-A. Also disclosed are methods of treating an neovascular disorder, such as cancer or an neovascular ocular disorder, using a PDGFR&#x3b2; and/or VEGF-A antagonist.

Compositions and methods for inhibiting PDGFRbeta and VEGF-A

Method treating neuronal tissue inflammation using an IL-31RA monoclonal antibody

Use of an IL-31 monoclonal antibody for antagonizing signal transduction in spinal cord cells

Compositions and methods for inhibiting PDGFR&#x3b2; and VEGF-A

Methods of antagonizing signal transduction in spinal cord cells using an IL-31Ra or OSMR-b antagonist

Growing community of inventors

Issaquah, WA, United States of America

Yue Yao