Alexion Pharmaceuticals, Inc.

Yuchun Zhang

Russell P Rother

Paul P Tamburini

Douglas L Sheridan

The present disclosure relates to, inter alia, antibodies, or antigen-binding fragments thereof, that bind to C5a and to use of the antibodies in methods for treating or preventing complement-associated disorders such as, but not limited to, atypical hemolytic uremic syndrome, age-related macular degeneration, rheumatoid arthritis, sepsis, severe burn, antiphospho lipid syndrome, asthma, lupus nephritis, Goodpasture's syndrome, and chronic obstructive pulmonary disease.

Anti-C5A antibodies

Anti-C5a antibodies

Methods of producing anti-C5a antibodies

The present disclosure relates to, inter alia, antibodies, or antigen-binding fragments thereof, that bind to C5a and to use of the antibodies in methods for treating or preventing complement-associated disorders such as, but not limited to, atypical hemolytic uremic syndrome, age-related macular degeneration, rheumatoid arthritis, sepsis, severe burn, antiphospholipid syndrome, asthma, lupus nephritis, Goodpasture's syndrome, and chronic obstructive pulmonary disease.

Methods of treating complement-associated disorders with anti-C5a antibodies

Nucleic acids encodng anti-C5A antibodies

Nucleic acids encoding anti-C5a antibodies

Growing community of inventors

Cheshire, CT, United States of America

Yuchun Zhang