Suzhou Sinovent Pharmaceuticals Co., Ltd.

Evopoint Biosciences Co., Ltd.

Sinomab Bioscience Limited

Yuchuan Wu

Yonghan Hu

Xi Chen

Shaoqiang Huang

Xiao Xi Liu

Xin Li

Dongdong Wu

Wei Peng

Jinlian Zhu

Bin Huang

Linhai Qu

Fan Hu

Jun Xian

Xiao Liu

The present invention provides a novel EZH2 inhibitor compound represented by formula (I) and a use of the inhibitor compound in preventing or treating a disease mediated by EZH2.

Polysubstituted benzene compound and preparation method and use thereof

Disclosed in the present invention are a heterocyclic compound, an application thereof and a pharmaceutical composition comprising the same. Provided by the present invention are a heterocyclic compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound has a novel structure and a good inhibitory activity against autotaxin (ATX). 

Heterocyclic compound, application thereof and pharmaceutical composition comprising same

Provided are a heterocyclic compound, a preparation method and the use thereof in medicine, and particularly involved are a heterocyclic compound for preventing and/or treating hypemricemia and gout, a preparation method and the use thereof in medicine. In particular, provided are a compound as shown in formula (I) and/or formula (II) or a tautomer thereof and a pharmaceutically acceptable salt thereof, a preparation method therefor and a method and the use thereof for treating hypemricemia and gout. 

Heterocyclic compound, preparation method and use thereof in medicine

Disclosed is a new crystal form of a 5-aminopyrazole carboxamide compound as shown in Formula (I). Also disclosed are a preparation method for said crystal form of said compound, a pharmaceutical composition of said crystal form of said compound, and uses thereof. 

Crystal form I of a 5-aminopyrazole carboxamide compound as BTK inhibitor

Provided are a &#x3b2;-lactamase inhibitor of formula (I), or an ester, a stereoisomer or a pharmaceutically acceptable salt thereof, and a method of preparing the same. Further provided is a pharmaceutical composition comprising the &#x3b2;-lactamase inhibitor of formula (I), or the ester, the stereoisomer or pharmaceutically acceptable salt thereof. In addition, the present invention relates to a method for treating diseases caused by bacterial infection, which comprises administering the &#x3b2;-lactamase inhibitor of formula (I), or the ester, the stereoisomer or the pharmaceutically acceptable salt thereof to a patient or a subject in need. 

&#x3b2;-lactamase inhibitor and use thereof

The present application discloses novel 5-aminopyrazole carboxamide compounds as shown in formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof. In addition, the present application further discloses a method for the preparation of the compounds, a pharmaceutical composition comprising a compound of the invention and the use of the compounds. 

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Beijing, China

Yuchuan Wu