Other

Celltech R&d Limited

Marina Biotech, Inc.

Garcia-Martinez, Leon Fernando

Chen, Yuching

Yuching Chen

Leon F Garcia-Martinez

Dawn Andrews

Michael E Houston, Jr

Kunyuan Cui

Lishan Chen

Sasha J Mayer

Dawn Michele Andrews

Leon Fernando Garcia-Martinez

Polynucleotide delivery-enhancing polypeptides are admixed or complexed with, or conjugated to, nucleic acids for enhancing delivery the nucleic acids into cells. The transported nucleic acids are active in target cells as small inhibitory nucleic acids (siNAs) that modulate expression of target genes, mediated at least in part by RNA interference (RNAi). The siNA/polypeptide compositions and methods of the invention provide effective tools to modulate gene expression and alter phenotype in mammalian cells, including by altering phenotype in a manner that eliminates disease symptoms or alters disease potential in targeted cells or subject individuals to which the siNA/polypeptide compositions are administered.

Compositions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells

The invention provides methods for modulating the immune system using anti-CD83 antibodies that can influence CD83 function.

Modulating immune responses

Antibodies to CD83

Growing community of inventors

Bellevue, WA, United States of America

Yuching Chen