Baidu Online Network Technology (beijing) Co., Ltd.

Chinese Academy of Medical Sciences

Hebei Medfaith Pharmaceutical Technology Co., Ltd.

Baidu Online Network Technology Co., Ltd.

Yucheng Wang

Tian Xia

Xun Sun

Juxian Wang

Hao Wang

Liang Wang

Shufu Xie

Yuqiang Zhai

Mei Zhu

Minghua Wang

Xuefu You

Xiaonan Du

Hongwei Tian

Maoxu Ge

Jinfeng Ren

Xingang Wang

Rongguang Shao

Naren Li

Guoning Zhang

Shi-Ying Cai

Mingjian Liu

Hongwei He

Shuangshuang Zhao

The present disclosure is related to the field of enzyme inhibitors, and in particular to a hydroxamic acid derivative, a method for producing the same and use thereof. The hydroxamic acid group of the hydroxamic acid derivative can be chelated with zinc ions in the LpxC active area, and the derivative has a hydrophobic side chain which can bind to hydrophic channels in the enzyme LpxC. These guarantee that the hydroxamic acid derivative has good bactericidal activity against Gram-negative bacteria and low toxicity. The present disclosure also provides a method for producing the hydroxamic acid derivative, which requires a shorter reaction time and can provide the derivative with a high yield.

Hydroxamic acid derivative, method for producing same and use thereof

Embodiments of the present disclosure disclose a method for position detection, a device, and a storage medium. The method includes: detecting a first lane line in a current image captured by a camera; performing an optimization on an initial transformation matrix reflecting a mapping relationship between a world coordinate system and a camera coordinate system based on a detection result of the first lane line; and obtaining a first 3D coordinate of a target object in the current image according to a transformation matrix optimized, and determining an ultimate 3D coordinate of the target object according to the first 3D coordinate.

Method for position detection, device, and storage medium

Embodiments of the present disclosure provide a method and an apparatus for generating three-dimensional data, a device, and a storage medium. The method comprises: obtaining a profile information annotation result for a target object in a two-dimensional image; calculating depth of field of the target object and a three-dimensional orientation of the target object according to the profile information annotation result and a standard three-dimensional size of the target object; determining a three-dimensional coordinate of a reference two-dimensional image point in the target object according to a two-dimensional coordinate of the reference two-dimensional image point in the two-dimensional image and the depth of field; and generating three-dimensional data matching the target object according to the three-dimensional coordinate of the reference two-dimensional image point and the three-dimensional orientation of the target object.

Method and apparatus for generating three-dimensional data, device, and storage medium

The embodiments of the present disclosure provide a method for processing 3D data, an apparatus for processing 3D data, a device and a storage medium. The method includes: acquiring three-dimensional point cloud data to be processed; mapping the three-dimensional point cloud data into a two-dimensional image space to obtain a first depth map; performing an expansion processing on the first depth map after changing an occlusion relation between target objects contained in the first depth map; and changing the occlusion relation between the target objects contained in the first depth map subject to the expansion processing to obtain a second depth map matched to the three-dimensional point cloud data.

Method and apparatus for mapping three-dimensional point cloud data, and storage medium

The invention belongs to the technical field of medicines. In particular, the invention relates to use of (benzenesulfonamido) benzamide compounds for inhibiting liver fibrosis, or preventing and/or treating a liver injury, or improving a liver function, or preventing and/or treating a liver disease associated with liver fibrosis, for modulating (e.g. reducing) the content of collagen (e.g. type I collagen) in liver tissue, for modulating (e.g. inhibiting) the activity of COL1A1 promoter in a cell, and for modulating (e.g. inhibiting) expression level of a gene associated with liver fibrosis in a cell.

Use of (benzenesulfonamido) benzamide compounds for inhibiting liver fibrosis

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Beijing, China

Yucheng Wang