Nitto-Denko Corporation

Yucheng Song

Lei Yu

Zheng Hou

Sang Van

Gang Zhao

Xinghe Wang

Zhongling Feng

Katsuyuki Okubo

Kenjiro Minomi

Chieko Kitaura

Jian Liu

Keisaku Okada

Natsuko Kagehisa

Masashi Kamiyama

Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.

Compositions that include a hydrophobic compound and a polyamino acid conjugate

Compositions and methods are disclosed for the treatment of diabetes and related diseases using peptides with incretin hormone activity. Preferably, the peptide with incretin hormone activity is GLP-1, exendin or an analog of GLP-1 or exendin. The peptides with incretin hormone activity are administered transepithelially using a transepithelial carrier peptide. The transepithelial peptide contains sufficient amino, guanidine or amidino groups to stimulate transepithelial delivery. In some embodiments, the transepithelial carrier and the peptide with incretin hormone activity are embedded in a pressure sensitive adhesive layer of a plaster or patch.

Transepithelial delivery of peptides with incretin hormone activities

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Salt Lake City, UT, United States of America

Yucheng Song