Affinergy Inc.

Carrus Capital Corporation

Biowest Therapeutics Inc.

Yuchen Chen

Paul Theodore Hamilton

Dale R Cameron

Shrikumar Ambujakshan Nair

Timothy J Krieger

Patricia J McNicol

Janet R Fraser

Jonathan Allen Hodges

Hanne Gron

Martyn Kerry Darby

Isaac Gilliam Sanford

Shafique Fidai

Sonia K Pawlak

Michelle Steffen Jansen

Evelina Rubinchik

Ganesan Sathya

Maria Marta Guarna

Donald B Borders

William V Curran

Qi Jia

Richard A Leese

Matthew B Nodwell

Vincent A Boyd

Dalia Isolda Juzumiene

Benjamin Marcus Buehrer

Paulo W M Sgarbi

Shirley A Wacowich-Sgarbi

Dominique Dugourd

Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or as an anti-inflammatory agent. In certain embodiments, the peptides are cationic peptides. The peptides are useful for the treatment of inflammatory diseases, such as microorganism-caused infections, acne, and psoriasis. The peptides and peptide formulations may be used topically or parenterally.

Antimicrobial and anti-inflammatory peptides

Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

Methods and compositions for soft tissue repair

The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.

Methods and compositions for delivery of growth factor to fibrous connective tissue

The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.

Compositions of lipopeptide antibiotic derivatives and methods of use thereof

Growing community of inventors

Chapel Hill, NC, United States of America

Yuchen Chen