Mediatek Singapore Pte. Ltd.

Mediatek Corporation

Hfi Innovation Inc.

Beijing Ql Biopharmaceutical Co., Ltd.

Sunplus Technology Co., Ltd.

Novo Nordisk A/s

Mediatek (beijing) Inc.

Beijing Ql Biopharmaceutical Co., Lt

Yuanyuan Zhang

Chia-Chun Hsu

Chia-Hao Yu

Yu-Syuan Conan Jheng

Per Johan Mikael Johansson

Aimin Justin Sang

Feifei Sun

Li Long Chen

Li-Chuan Tseng

I-Kang Fu

Jiann-Ching Guey

Wei Guo

Chun-Fan Tsai

Bo Wu

Ming-Po Chang

Haixia Zou

Xu Chen

Yung-Hsiang Liu

Peng Zhai

Xinyu Zhao

Yaoguang Jin

Pavan Santhana Krishna Nuggehalli

Yuan-Wen Ting

Tsung-Liang Lu

Xinle Wu

Pei-Shan Kao

Tao Chen

Chien-Chun Huang-Fu

Yih-Shen Chen

Peter Madsen

Xuelong Wang

Yen-Chen Chen

Guillaume Sebire

Hsuan-Li Lin

Guan-Yu Lin

Shiang-Jiun Lin

Tsang-Wei Yu

Janos Tibor Kodra

Ming-Yuan Cheng

Thomas Boerglum Kjeldsen

Pradeep Jose

Tina Moeller Tagmose

Jianwei Zhang

Li Chen

Yuying Zhang

Ting Chen

Martin Werner Borchsenius Muenzel

Lennart Lykke

Lingli Zeng

Xiaona Dong

Zuobin Wang

Lone Pridal

Zhe Wan

Zhaosheng Lin

Leonardo De Maria

Guo Hau Gau

Chi-Yuan Peng

Xiaonan Zhang

Apparatus and methods are provided for mobility interruption reduction. In novel aspect, dual-protocol stack handover is performed with zero or close to zero mobility interruption. In one embodiment, the UE receives PDCP SDU from upper layers for UL transmission and is configured with a protocol stack associated with a source gNB and a target gNB for handover. The UE associates a COUNT value corresponding to TX_NEXT to the PDCP SDU, selects an UL gNB as a destination gNB for UL transmission, performs header compression with a robust header compression (ROHC) profile based on the UL gNB. In one embodiment, the UE selects the UL gNB when an UL grant is received from the selected gNB. In another embodiment, corresponding ROHC profiles are configured by the wireless network. In one embodiment, the ROHC profile for the UL gNB is configured by the selected UL gNB.

Dual protocol for mobility enhancement

The present disclosure provides polypeptide conjugates comprising GLP-1 receptor agonist and a peptide linker, and liquid pharmaceutical compositions comprising the same. Methods of using such for treating diseases are also provided.

Liquid pharmaceutical compositions of polypeptide conjugates and methods of uses thereof

Apparatus and methods are provided for reliable multicast transmission with compact protocol stack. In one novel aspect, compact protocol stacks are configured for the UE and the base station handling both the PTM RB and the PTP RB. The compact protocol stack is either configured a compact RLC entity or a compact PDCP entity. The UE monitors a PTM LCH and a PTP LCH and sends feedback to the network with the PTP RB. The base station transmits MBS data packets in the PTM mode to the one or more subscriber UE, monitors feedback report from each subscriber UEs through corresponding PTP RB, and retransmits MBS data packets to one or more UEs through corresponding PTP RBs based on corresponding feedback reports. PTM-to-PTP and PTP-to-PTM mode switches are performed when triggering events are detected. The mode switch notification is sent to UEs via MAC CE or RLC control PDU.

Reliable multicast transmission with compact protocol stack

Apparatus and methods are provided for connectionless data transfer. In one novel aspect, the UE in INACTIVE state initiates one or more data transmissions without RRC connection upon determining one or more preconfigured transmission conditions. The UE restores an INACTIVE AS context, establishes UL resources, and performs connectionless data transmissions. The UE monitors one or more preconfigured fallback conditions for fallback procedures and monitors stop conditions for suspension/stopping procedures. In one embodiment, the UL resources for the one or more data transmission are preconfigured configuration grant (CG) resources from the network. In one embodiment, the preconfigured UL resource is used for the data transmission only when the TA is valid. When the TA is not valid, the UE performs RA procedure and either uses the preconfigure resource or continues the one or more data transmissions by monitoring PDCCH with C-RNTI.

Methods and apparatus for data transmission in connectionless way

The present disclosure provides conjugates of polypeptides comprising nanobody and FGF21 linked by a polypeptide linker. The present disclosure further provides conjugates of polypeptides comprising GLP-1, nanobody, and FGF21 linked by two polypeptide linkers respectively. Pharmaceutical compositions comprising the same and methods of treating diseases are also provided.

Fusion polypeptides for metabolic disorders

Methods and apparatus are provided for UE-triggered handover and early preparation with coexistence of the network-triggered handover. In one novel aspect, the UE is configured early measurement report configuration, receives an early handover command from the serving base station with a handover candidate cell list, monitors handover triggering conditions for each candidate cell on the handover candidate cell list based on a UE-triggered handover configuration and performs the UE-triggered handover to a candidate cell when the corresponding triggering condition is met for the candidate cell. In one embodiment, the UE receives a network-triggered handover command to a target cell, suspends the UE-triggered handover configuration and performs the network-triggered handover to the target cell. The UE discards the UE-triggered handover configuration upon success of the network-triggered handover and resumes the UE-triggered handover configuration upon failure of the network-triggered handover.

User equipment (UE)-triggered handover with early preparation in mobile networks

The present disclosure provides fusion polypeptides comprising serum albumin binding single domain antibody and GDF15, the polypeptide complexes thereof. Pharmaceutical compositions comprising the same and methods of treating diseases are also provided.

Fusion proteins of GDF15 and use thereof

A User Equipment (UE) including a wireless transceiver and a controller is provided. The wireless transceiver performs wireless transmission and reception to and from a first cellular station and a second cellular station. The controller continues to send or receive UP data to or from the first cellular station via the wireless transceiver after receiving a handover command message for a handover of the UE from the first cellular station to the second cellular station, and receives a Radio Resource Control (RRC) request message from the second cellular station via the wireless transceiver after sending a handover complete message to the second cellular station. Also, the controller detaches from the first cellular station in response to receiving the RRC request message.

Enhanced handover methods and apparatuses using the same

The present disclosure provides a polypeptide conjugates comprising GLP-1 receptor agonist and a peptide linker, and pharmaceutical compositions comprising the same. Methods of using such for treating diseases are also provided.

Polypeptide conjugates and methods of uses

The present disclosure provides conjugates of polypeptides comprising GLP-1, polypeptide linker and FGF21. Pharmaceutical compositions comprising the same and methods of treating diseases are also provided.

Conjugates of fusion proteins of GLP-1 and FGF21

Aspects of the disclosure provide a method of beam failure handling. The method can include performing beam quality measurement of one or more beams transmitted from a base station (BS) at a user equipment (UE) in a beamformed wireless communication system, determining a beam failure occurs based on the beam quality measurement, and performing a beam recovery process that includes at least one of a contention-free beam recovery process or a contention-based beam recovery process. The one or more beams are used for transmitting physical downlink control channels (PDCCHs).

Methods and apparatus supporting beam failure recovery in system with multiple-beam operation

This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.

Oligomer extended insulin-Fc conjugates

The present disclosure provides fusion polypeptides comprising GLP-1 and GDF15, the polypeptide complexes, and the conjugates thereof. Pharmaceutical compositions comprising the same and methods of treating diseases are also provided.

Fusion proteins of GLP-1 and GDF15 and conjugates thereof

Apparatus and methods are provided to reduce mobility interruption time through dual-protocol stacks for mobility enhancement. In novel aspect, the UE configures a target protocol stack for a target gNB upon receiving a reconfiguration message from a source gNB, performs random access procedure and establishes RRC connection with the target gNB through the target protocol stack while simultaneously maintaining data transmission and reception with the source gNB, and releases the source RRC connection with the source gNB and performs data transmission and reception with the target gNB upon detecting one or more predefined release triggering event. In one embodiment, the target protocol stack includes a PHY layer, a MAC layer, and RLC layer, a PDCP and optionally a SDAP. In one embodiment, the UE enables a PDCP reordering, wherein the PDCP reordering is performed on PDCP packet data units received from the source and the target protocol stacks.

Dual-protocol for mobility enhancement

Growing community of inventors

Beijing, China

Yuanyuan Zhang