Boe Technology Group Co., Ltd.

Beijing Boe Optoelectronics Technology Co., Ltd.

Peking University

Beijing Vitalstar Biotechnology Co., Ltd.

Beihao Stem Cell and Regenerative Medicine Translational Research Institute

Yuanyuan Du

Hao Zhang

Lili Chen

Jian Qiao Sun

Jun Xu

Jinghua Miao

Bin Zhao

Ziqiang Guo

Feng Zi

Yakun Wang

Feng Pan

Jinlin Wang

Yu Lei

Xinjian Liu

Ruifeng Qin

Yan Shi

Hongkui Deng

Ming Yin

Nan Song

Jun Jia

Chengang Xiang

A method for inducing reprogramming of a cell of a first type which is not a non-hepatocyte (non-hepatocyte cell), into a cell with functional hepatic drug metabolizing and transporting capabilities, is disclosed. The non-hepatocyte is induced to express or overexpress hepatic fate conversion and maturation factors, cultured in somatic cell culture medium, hepatocyte cell culture medium and hepatocyte maturation medium for a sufficient period of time to convert the non-hepatocyte cell into a cell with hepatocyte-like properties. The iHeps induced according to the methods disclosed herein are functional induced hepatocytes (iHeps) in that they express I and II drug-metabolizing enzymes and phase III drug transporters and show superior drug metabolizing activity compared to iHeps obtained by prior art methods. The iHeps thus provide a cell resource for pharmaceutical applications.

Methods for reprograming non-hepatocyte cells into hepatocyte cells

A current compensation circuit, a virtual reality device and a control method are disclosed. The current compensation circuit includes: a first constant current sub-circuit, configured to generate a driving current of a backlight module; a second constant current sub-circuit, configured to generate a compensation current of the backlight module; a compensation gating sub-circuit, configured to determine whether to select the second constant current sub-circuit to supply power to the backlight module; and a black insertion control signal generation sub-circuit, configured to generate a black insertion control signal, connected with the first constant current sub-circuit and the compensation gating sub-circuit, and configured to control, by the black insertion control signal, the first constant current sub-circuit and the second constant current sub-circuit to simultaneously supply power to or power off the backlight module, so that the black light module realizes a backlight black insertion.

Current compensation circuit, virtual reality device and control method

Growing community of inventors

Beijing, China

Yuanyuan Du