Amgen Inc.

Snapdragon Chemistry, Inc.

Yuanqing Fang

Matthew Bio

Sebastien Caille

Filisaty Vounatsos

Brian McNeil Cochran

Sarah Wortman

Lawrence R McGee

Brian M Fox

Brian Stuart Lucas

Sean H Wiedemann

Brian Mcneil Cochran

Adrian G Amador

Brian S Lucas

Lawrence R Mcgee

Jason S Tedrow

Steven Mennen

Babak Riahi

Eric A Bercot

Robert Ronald Milburn

David D Ford

John T Colyer

Johann Chan

Ryan M Spoering

Jillian Sheeran

Timothy J Doherty

Matthew M Bio

Grace Russell

Mikhail V Goncharuk

Embodiments described herein relate generally to continuous flow photoreactors with easily replaceable and adjustable components. The photoreactor includes a reactor flow system, a lighting system, and a temperature control system. The reactor flow system includes a reactor inlet port, a reactor outlet port, and a length of reactor tubing fluidically coupled to the reactor inlet port and reactor outlet port. The lighting system includes a light emitting apparatus (e.g., a plurality of LEDs) configured to emit light in a defined wavelength range toward the length of reactor tubing. The temperature control system includes an inlet port, an outlet port, and a length of temperature control tubing fluidically coupled to the inlet port and the outlet port. In some embodiments, the temperature control system can be configured to circulate a fluid to cool the lighting system.

Continuous flow photoreactor

The present disclosure relates to a computer-implemented method for analyzing a product stream of a chemical reaction. The method includes withdrawing a portion of the product stream of the chemical reaction from a reactor, the portion of the product stream having a volume of less than about 200 μL. The method further includes mixing the portion of the product stream with a diluent to produce a sample and then transferring the sample to a liquid chromatography device. A measured chemical profile is then developed, via the liquid chromatography device, which can be used for process monitoring or real time decision making. In some embodiments, the method can include adjusting a reaction condition in the reactor based on differences between the measured chemical profile and a desired chemical profile.

Automated online chromatographic sample dilution and preparation system

The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

Processes of making and crystalline forms of a MDM2 inhibitor

The present invention relates to processes for preparing protected glyceraldehydes, such as (hydroxy)methanesulfonates. In addition, the invention relates to thiadiazoles, particularly 3-diooxolanyl-thiadiazoles.

Method for the preparation of thiadiazoles

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Belmont, MA, United States of America

Yuanqing Fang