Zhejiang Jiuzhou Pharmaceutical Co., Ltd.

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Gilead Pharmasset LLC

Zhejiang Jiuzhou Pharmaceuticals Co., Ltd

Zhejiang Jiuzhou Pharma Science & Technology Co., Ltd.

Yuanqiang Li

Daqing Che

Bin Zhang

Guoliang Zhu

Xianyi Zhang

Hongjun Gao

Rongmin Chen

Pucha Yan

Jianbing Zheng

Jianqiang Zhao

Kang Zhen Chen

Lingfeng Qian

Wenfa Ye

Tianhao Zhu

Yunyu Hua

Yongliang Yan

Xiangdong Zhang

Xiaocong Zhou

Jianqiang Qian

Xiaowei Hu

Teruo Umemoto

Kang Chen

Halogenated S-(perfluoroalkyl)dibenzothiophenium salt represented by the following general formula (I):  This compound is a new, reactive, and industrially useful reagent for perfluoroalkylating organic compounds. The reagent can be prepared by a one-pot process or a two-step reaction process from a halogenated biphenyl and easily isolated by a filtration method. In addition, the halogenated biphenyl can be recovered by desulfurization from a halogenated dibenzothiophene obtained as a side-product by the usage of the reagent.

Halogenated S-(perfluoroalkyl)dibenzothiophenium salt and its production methods

The present invention relates to the technical field of organic chemistry, specifically an asymmetrical hydrogenation of an &#x2202;-ketonic acid compound, the technical proposal being as shown by the following formula:  Wherein Ris a phenyl, a substituted phenyl, a naphthyl a substituted naphthyl, a C-Calkyl or aralkyl, the substitute is a C-Calkyl, a C-Calkoxy, a halogen, the number of the substituents is 1-3. M is a chiral spiro-pyridyl amido phosphine ligand iridium complex having the following structure,  Wherein, R is hydrogen, 3-methyl, 4-Bu or 6-methyl

Asymmetrical hydrogenation reaction of ketonic acid compound

The present invention relates to the technical field of ibrutinib, particularly to the technical field of ibrutinib intermediate compounds and preparation methods thereof. The intermediate compounds are represented by formula A, wherein, the dotted line represents a double bond or a single bond between carbon and oxygen. 

Ibrutinib intermediate compounds, preparation methods and uses thereof

The present invention relates to the field of medical synthesis, in particular to a preparation method for pyrrolidine-2-carboxylic acid derivatives. The present invention adopts the following technical solution: providing a compound having a structure of formula (E), wherein R is Ror R, Ris C-Can alkyl, benzyl, p-methoxybenzyl, or p-nitrobenzyl group, and Ris hydrogen; Ris a protecting group of the carboxyl group; and Pis a protecting group on nitrogen. 

Preparation method for pyrrolidine-2-carboxylic acid derivatives

A novel process for the preparation of a fluorolactone derivative of the formula   The acylated fluor lactones of formula V, particularly the benzoyl derivative with R=benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.

Process for the preparation of a fluorolacton derivative

A novel process for the preparation of a fluorolactone derivative of the formula   The acylated fluorolactones of formula V, particularly the benzoyl derivative with R=benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.

The present invention relates to the technical field of medicine and organic synthesis, particularly to a method for preparing crizotinib. The method comprises the compound of formula b and the compound of formula e undergoing Suzuki coupling reaction to produce the compound of formula a which then was subjected to deprotection to afford (&#xb1;) crizotinib. 

Crizotinib preparation method

Disclosed are a silodosin intermediate and a preparation method thereof. The silodosin intermediate has the structure shown by the formula (A). X is hydrogen or bromide and Ris hydrogen. The formyl group may be a group having the structure shown by the formula I. Ris a protecting group of carboxyl, and Ris 3-hydroxypropyl or a group having the structure shown by the formula II. W is a protecting group of hydroxyl. A compound of the formula (A) according to the present invention may further be used for preparing a compound having the structure shown by the formula (D). By means of the intermediate and the preparation method therefor provided by the present invention, high-purity optically pure silodosin can be obtained, and the optical purity is above 99%. 

Silodosin intermediate and preparation method therefor

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Taizhou, China

Yuanqiang Li