University of California

Yuanpei Li

Kit S Lam

Kai Xiao

Juntao Luo

Chong-Xian Pan

Tzu-yin Lin

Xiangdong Xue

Yee Huang

Zhao Ma

Caihong Feng

Gaurav Bharadwaj

Chongxian Pan

The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, nanoparticles and nanocarriers are useful for treating cancers and other diseases, as well as for imaging diseased tissue or organs.

Conjugates of active pharmaceutical ingredients

Methods and compositions are provided for hybrid telodendrimers and nanocarriers containing such hybrid telodendrimers.

Hybrid telodendrimers

The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

Porphyrin modified telodendrimers

Reversibly crosslinked micelle systems

The present invention provides a nanoparticle including at least one poly(vinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa, substituted with one or more moieties selected from: a therapeutic agent having a boronic acid moiety, wherein the therapeutic agent is covalently linked to the PVA via a boronate ester bond; a crosslinking group having a disulfide moiety, wherein the crosslinking group is covalently linked to the PVA, and a porphyrin, wherein the porphyrin is covalently linked to the PVA. Use of the nanoparticles for tumor detection and the treatment of diseases, including methods for photodynamic therapy and photothermal therapy, are also described.

Poly(vinyl alcohol) nanocarriers

Growing community of inventors

Elk Grove, CA, United States of America

Yuanpei Li