Baxter International Inc.

Baxter Healthcare Sa

Millipore Corporation

Emd Millipore Corporation

Baxter Healthcare Inc.

Fenwal, Inc.

Cerus Corporation

Yuanpang Samuel Ding

Ying-Cheng Lo

Justin Belanger Rohde

Shincy J Maliekkal

Joseph V Ranalletta

Bernd Krause

Ye Chen

Mark Edward Pasmore

Grant Anthony Bomgaars

Michael Joseph Sadowski

Cristian Adolfo Menzel Bueno

Thomas Edward Dudar

Rosa Yeh

Joel Titus

Anastasios Hristakos

Chuan Qin

Lecon Woo

Birendra K Lal

Patrick T Ryan

Donna L Rostron

Susan R Mizener

Atif M Yardimci

Donald D Busby

Jeff White

Kevin Cooper

Ieng Kin Lao

Robert W Childers

Thomas D Kelly

Rodolfo G Roger

Michael E Hogard

Donald Smith

Joshua James Miller

Michael T Ling

Serhan Acikgoz

Mark E Jablonski

Rosa Hung-Chen Yeh

Katherine M Holian

Matthew R Muller

Gert Najdeni

Sujatha Karoor

Michael T K Ling

Moh-Ching Oliver Chang

Mark Joseph Doty

Patrick Lee

William S Hurst

James Mitchell White

William Patrick Burns

Brian Connell

Michael Tung-Kiung Ling

William R Griswold

Rongsheng Lin

Stephane Dupont

Martin F Miller

Jacob Daniel Rivett

Aaron W Brown

Zachariah Louis Fuller

Aaron Joseph Geier

Alan John Harvey

Leansu Kiatoukaysy Lo

Bernard J Lyons

Roshni S Barot

Steven C Jepson

George D Cimino

Dean G Laurin

Brian Lauman

Daniel F Bischof

Anders John Wellings

Karl Hans Cazzini

Marc Steven Minkus

Gideon Hecht

Douglas W Reitz

James M White

Gregg Nebgen

Michael R Prisco

James S Slepicka

James Laird

Christine L Rebbeck

John Edward Steck

Andrey Kopychev

Alp Akonur

Derek J Hei

Richard E Kienman

Dustin Christopher Cawthon

William Chan

Peyton S Metzel

Mahmood Mohiuddin

Robert E Herman

Chi J Chen

Tom Johnson

Veronique Mayaudon

Jennifer S Lindsay

Jerry Ripley

Joseph S Moore

Dan Roush

George F Bobart

Amy L Twining

Mehmet B Ozer

Jean-Michel Vallee

Tan-Cheng Chou

A urea separation apparatus is described herein. In an embodiment, the urea separation apparatus includes a blood compartment that is a part of an extracorporeal circuit fluidly connected to a patient and configured to receive blood of the patient. The apparatus also includes a waste membrane enclosing the blood compartment that is configured to filter waste from the blood. The apparatus further includes a dialysis fluid compartment located on an opposite side of the waste membrane from the blood compartment. The dialysis fluid compartment includes dialysis fluid that absorbs the waste from the waste membrane. The apparatus moreover includes a charged membrane enclosing the dialysis fluid compartment. The charged membrane is configured to filter at least a portion of the waste from the dialysis fluid. Additionally, the apparatus includes a urea compartment that circulates secondary fluid for absorbing the portion of the waste from the charged membrane.

Methods and apparatuses using urea permselective diffusion through charged membranes

A medical product includes a bladder, a filtration device, and a sterile product concentrate. The bladder has a perimeter seal and defining a sterile chamber. The filtration device includes a stem and a filter membrane disposed in line with the stem. The stem extends through the perimeter seal and has an inlet end accessible from outside of the perimeter seal and an outlet end in fluid communication with the sterile chamber. The filter membrane can have a nominal pore size in a range of approximately 0.1 μm to approximately 0.5 μm, wherein the filter membrane is shaped as a hollow fiber with a wall and pores residing in the wall of the fiber. The sterile product concentrate is disposed in the sterile chamber and adapted to be reconstituted by the introduction of a pharmaceutical fluid into the chamber through the filtration device.

Medical product including pre-filled product bag

A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.

Balanced flow dialysis machine

The present disclosure provides devices and methods of using same for cleansing a solution (e.g., a salt or used dialysis solution) of urea via electrooxidation, and more specifically to cleansing a renal therapy solution/dialysis solution of urea via electrooxidation so that the renal therapy solution/dialysis solution can be used or reused for treatment of a patient. In an embodiment, a device for the removal of urea from a fluid having urea to produce a cleansed fluid includes a urea decomposition unit and an electrodialysis unit.

Devices for urea electrolysis and methods of using same

Compositions for regeneration of spent dialysis fluid are disclosed. The compositions include a sorbent comprising a titanium-glyoxal complex. Sorbent cartridges comprising the sorbents, and methods and systems for using the cartridges in dialysis also are disclosed.

Method and composition for removing uremic toxins

Methods, sorbent cartridges and cleaning devices are disclosed for refurbishing sorbent materials. In one implementation among multiple implementations, a medical fluid delivery method includes: providing a sorbent cartridge including HZP within a casing for a treatment; and after the treatment, refurbishing the HZP while maintained within the casing via (i) regenerating the non-disinfected HZP by flowing an acid solution through the casing, (ii) rinsing the regenerated HZP while maintained within the casing, (iii) disinfecting the regenerated and rinsed HZP by flowing a disinfecting agent through the casing, and (iv) rinsing the regenerated and disinfected HZP while maintained within the casing. Multiple batch sorbent refubishing implementations are also disclosed.

Systems and methods for batch sorbent material reuse

A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.

Terminal sterilization filtration closed lyophilization in a container

A system for reconstituting and sterilizing a concentrate includes a mixing container, a filtration device, and a product bag. The a mixing container has an inlet port and outlet port in fluid communication with a mixing chamber disposed between the inlet port and the outlet port. The mixing chamber is adapted to contain a product concentrate. The filtration device has an inlet and an outlet, the inlet of the filtration device coupled to the outlet port of the mixing container. The filtration device includes a filter membrane with a nominal pore size in a range of approximately 0.1 &#x3bc;m to approximately 0.5 &#x3bc;m. The product bag has an inlet port coupled to the outlet of the filtration device, and has a bladder defining an empty sterile chamber for receiving sterilized and reconstituted product resulting from mixing a diluent with a product concentrate in the mixing chamber to obtain a mixture then introduced through the filtration device to obtain the reconstituted and sterilized product.

Dual container system for product reconstitution

A dialysis method and system for determining an amount of total chlorine in a partially purified water sample is disclosed. The system includes a water machine that produces at least partially purified water including an at least partially purified water sample and a dialysis machine that provides a dialysis treatment to a patient. The dialysis machine receives the at least partially purified water from the water machine to prepare dialysis fluid for the dialysis treatment. The system also includes a total chlorine detector configured to receive the at least partially purified water sample, at a first time apply a source voltage to the at least partially purified water sample, and at a second time stop applying the source voltage to the at least partially purified water sample and instead monitor a sensed electrical parameter to determine an amount of total chlorine in the at least partially purified water sample.

Method of determining an amount of total chlorine in a water sample for a hemodialysis treatment

A method of providing a plurality of filled product bags of sterile fluid includes positioning a bag assembly onto a filling machine. The bag assembly includes a tube, a filter assembly, bladders, and stems. A stem is attached to a bladder, forms a fluid passageway, fluidly connects to the tube, and provides fluid communication into the bladders. The method includes fluidly coupling an inlet of the filter assembly to a connection line in fluid communication with a fluid source, and filling the bag assembly with a fluid. Filling the bag assembly includes passing the fluid through the filter assembly, the fluid passageway, and into the bladder. The method includes sealing the fluid passageway at a location between the tube and the bladders. The method includes cutting the stem to form a partially filled product bag having the sealed passageway. The method includes performing an integrity test on the filter assembly.

Method and machine for producing sterile solution product bags

A sterile solution product bag includes sterilization grade filter integrated directly into the product bag such that microbial and particulate matter filtration can be performed using the filter directly at the point of fill. The filter can include a hollow fiber filter membrane contained in a stem connected to a bladder of the product bag.

Sterile solutions product bag

A gravity fed peritoneal dialysis ('PD') machine includes: a frame configured to be set on a supporting surface; at least one load cell; a scale platform supported by the frame via the at least one load cell positioned between the frame and the scale platform; a drain container support in mechanical communication with and extending downwardly from the scale platform, the machine configured such that when the frame is set on the supporting surface, at least one fresh PD fluid supply container is supportable by the scale platform above the at least one load cell and at least one used PD fluid drain container is supportable by the drain container support below the at least one load cell, so that a combined weight of fresh PD fluid and used PD fluid may be sensed by the at least one load cell.

Gravity fed dialysis systems and methods

A syringe system includes a syringe and a filtration device connected to the syringe for sterilizing and introducing fluid into the syringe. The syringe includes a syringe barrel having a proximal end defining a barrel opening, a distal end defining a delivery opening, a bore extending between the proximal end and the distal end, and a stopper disposed in the bore of the syringe barrel. The filtration device has an inlet and an outlet coupled in fluid communication with the delivery opening at the distal end of the syringe barrel. The filtration device includes a stem and a filter membrane disposed in line with the stem. The filter membrane optionally has a plurality of pores each with a nominal pore size in a range of approximately 0.1 &#x3bc;m to approximately 0.5 &#x3bc;m such that a pharmaceutical fluid can be introduced as a sterilized pharmaceutical fluid into the bore of the syringe barrel by passing through the filtration device.

Medical syringe system with filtered filling port

A product bag includes a bladder and an elongated filtration device. The bladder includes opposing first and second film layers defining a product chamber. The first and second film layers are sealed together along a perimeter seal extending along at least a portion of a perimeter of the bladder. The elongated filtration device includes a housing, a filtration membrane disposed in the housing, an inlet adapted for receiving a fluid to be filtered, and an outlet in fluid communication with the product chamber. A majority of the elongated filtration device is embedded between the first and second film layers of the perimeter seal of the bladder to provide for a compact form factor.

Filtered product bag with compact form factor

Growing community of inventors

Libertyville, IL, United States of America

Yuanpang Samuel Ding