Neuboron Medtech Ltd.

Yuanhao Liu

Weilin Chen

Ming-Chen Hsiao

Peiyi Lee

Chiung-Wen Tsai

Zheng Wang

Jing He

Shihong Li

Zhigang Luo

The present disclosure provides a neutron capture therapy system, including an accelerator for generating a charged particle beam, a neutron generator for generating a neutron beam having neutrons after irradiation by the charged particle beam, and a beam shaping assembly for shaping the neutron beam. The beam shaping assembly includes a moderator and a reflecting assembly surrounding the moderator. The neutron generator generates the neutrons after irradiation by the charged particle beam. The moderator moderates the neutrons generated by the neutron generator to a preset energy spectrum. The reflecting assembly includes a reflecting assembly to deflected neutrons back to the neutron beam and a supporting member to support the reflectors. A lead-antimony alloy is for the reflecting assembly to mitigate a creep effect that occurs when only a lead material is for the reflectors, thereby improving the structural strength of a beam shaping assembly.

Neutron capture therapy system comprising a beam shaping assembly configured to shape a neutron beam

The present disclosure provides a neutron capture therapy system, including a neutron generator to generate neutrons after irradiation by charged particles, and a beam shaping assembly includes a moderator and a reflector surrounding the moderator. A vacuum tube connected to the accelerator is provided at an accommodating portion. The vacuum tube transmits the charged particles accelerated by the accelerator to the neutron generator to generate neutrons. The neutron generator moves between a first position and a second position, at the first position, the neutron generator react with the charged particle beam to generate neutrons, at the second position, the neutron generator falls off the beam shaping assembly. The vacuum tube is detached to make the neutron generator fall off the beam shaping assembly, to reduce direct contact of a worker with the neutron generator after nuclear reactions, thereby reducing radioactive hazards for workers.

Neutron capture therapy system

Provided is a radiation detection system for improving the accuracy of a neutron beam irradiation dose for a neutron capture therapy system. The neutron capture therapy system includes a charged particle beam, a charged particle beam inlet for passing the charged particle beam, a neutron generating unit for generating the neutron beam by means of a nuclear reaction with the charged particle beam, a beam shaping assembly for adjusting flux and quality of the neutron beam, and a beam outlet adjoining to the beam shaping assembly, the radiation detection system includes a radiation detection device arranged within the beam shaper or outside the beam shaping assembly, the radiation detection device is used for real-time detection of the overflowing neutron beam by the neutron generating unit or the generated &#x3b3;-ray after the nuclear reaction of the charged particle beam with the neutron generating unit.

Radiation detection system and radiation detection method for neutron capture therapy system

A neutron capture therapy system includes an accelerator for accelerating charged particles to generate a charged particle beam, a beam transmitting device, and a neutron beam generating device. The neutron beam generating device further includes a first, a second and a third neutron beam generating device. The beam transmitting device further includes a first transmitting device connected to the accelerator, a beam direction conversion device configured to switch a traveling direction of the charged particle beam, and a second, a third and a fourth transmitting device that respectively transmit the charged particle beam from the beam direction conversion device to the first, the second and the third neutron beam generating device, wherein two of the first, the third and the fourth transmitting device define a first plane, a first and a second transmitting device define a second plane, and the first plane is different from the second plane.

A neutron capture therapy system includes an accelerator for generating a charged particle beam, a neutron generator for generating a neutron beam having neutrons after irradiation by the charged particle beam, and a beam shaping assembly for shaping the neutron beam. The beam shaping assembly includes a moderator and a reflecting assembly surrounding the moderator. The neutron generator generates the neutrons after irradiation by the charged particle beam. The moderator moderates the neutrons generated by the neutron generator to a preset energy spectrum. The reflecting assembly includes a plurality of reflectors configured to guide deflected neutrons back to the neutron beam and a supporting member to support the plurality of reflectors. A lead-antimony alloy is for the reflecting assembly to mitigate a creep effect that occurs when only a lead material is for the plurality of reflectors, thereby improving the structural strength of a beam shaping assembly.

A neutron capture therapy system, including a beam shaping assembly, and a vacuum tube and at least one cooling device. The beam shaping assembly includes a beam inlet, an accommodating cavity accommodating the vacuum tube, a moderator adjacent to an end portion of the accommodation cavity, a reflector surrounding the moderator, and a radiation shield and a beam outlet arranged in the beam shaping assembly. An end portion of the vacuum tube is provided with a target. The cooling device undergoes a nuclear reaction with a charged particle beam incident from the beam inlet to produce neutrons. The moderator decelerates the neutrons produced by the target to an epithermal neutron energy region. The reflector leads deviating neutrons back to the moderator. At least one accommodating pipeline accommodating the cooling device is arranged in the beam shaping assembly. A filler is filled between the cooling device and the accommodating pipeline.

Provided is a beam diagnostic system for a neutron capture therapy system. The neutron capture therapy system includes a charged particle beam, a charged particle beam inlet for passing the charged particle beam, a neutron generating unit generating a neutron beam by a nuclear reaction with the charged particle beam, and a beam shaping assembly for adjusting flux and quality of the neutron beam generated by the neutron generating unit and a beam outlet adjoining to the beam shaping assembly. The charged particle beam inlet is accommodated into the beam shaping assembly and the neutron generating unit is accommodated in the beam shaping assembly. The beam diagnostic system includes a charged particle beam diagnostic device and a neutron beam diagnostic device, and the beam diagnostic system is used to simultaneously diagnose whether the neutron capture therapy system and/or the beam diagnostic system is malfunctioning.

Beam diagnostic system for neutron capture therapy system

The present disclosure provides a beam shaping assembly for neutron capture therapy, wherein the beam shaping assembly includes a neutron generating device, a moderator, a disturbing unit and a beam outlet. The neutron generating device is used to generate neutrons that form a neutron beam in a direction from the neutron generating device to the beam outlet, the moderator adjacent to the neutron generating device for adjusting fast neutrons in the neutron beam to epithermal neutrons. The disturbing unit is located between the moderator and the beam outlet for passing through the neutron beam and reducing the gamma ray content in the neutron beam passing through the beam outlet. The technical solution provided by the present disclosure can effectively reduce the gamma ray content in the neutron beam under the premise that the quality of the neutron beam is not significantly adversely affected.

Beam shaping assembly for neutron capture therapy

In order to provide a neutron therapy apparatus which give multi angles neutron beam irradiation, the neutron therapy apparatus includes: a beam shaping assembly including a moderator and a reflector surrounding the moderator, wherein the moderator moderates neutrons to a predetermined energy spectrum and the reflector guides deflected neutrons back to enhance the neutron intensity in the predetermined energy spectrum; a neutron generator embedded inside the beam shaping assembly, wherein the neutron generator generates neutrons after irradiated by an ion beam; and an irradiation room for receiving a irradiated object, a shielding assembly connected to the beam shaping assembly, wherein the shielding assembly moves together with the beam shaping assembly and shields the radioactive rays leaked from the beam shaping assembly all the time.

Neutron therapy apparatus

Provided is a geometric model establishment method based on medical image data, including: a step of reading medical image data; a step of defining a tissue type by a conversion relationship between the medical image data and the tissue type; a step of deciding the number of tissue clusters; a step of defining a tissue density by a conversion relationship between the medical image data and the density; a step of establishing 3D encoding matrix with information about the tissue and the density; and a step of generating a geometric model. According to a conversion relationship between medical image data and a tissue type, the number of tissue clusters can be determined according to actual requirements, so that the tissue type, the element composition and the density are provided more accurately, and an established geometric model is better matched to the real situation reflected by the medical image data.

Geometric model establishment method based on medical image data

In order to improve flux and quality of neutron sources, the disclosure provides a beam shaping assembly for neutron capture therapy includes: a beam inlet; a target, wherein the target has nuclear reaction with an incident proton beam from the beam inlet to produce neutrons; a moderator adjoining to the target, wherein the neutrons are moderated by the moderator to epithermal neutron energies, the moderator includes a main body and a supplement section surrounding the main body, the main body and the supplement section form at least a tapered structure; a reflector surrounding the moderator; a thermal neutron absorber adjoining to the moderator; a radiation shield arranged inside the beam shaping assembly, wherein the radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation; and a beam outlet.

In order to provide a neutron therapy apparatus which give multi angles neutron beam irradiation, the neutron therapy apparatus includes: a beam shaping assembly including a moderator and a reflector surrounding the moderator, wherein the moderator moderates neutrons to a predetermined energy spectrum and the reflector guides deflected neutrons back to enhance the neutron intensity in the predetermined energy spectrum; a neutron generator embedded inside the beam shaping assembly, wherein the neutron generator generates neutrons after irradiated by an ion beam; at least a tube for transmitting the ion beam to the neutron generator, wherein the tube defines at least an axis; deflection magnets for changing the transmission direction of the ion beam; a collimator for concentrating neutrons; and an irradiation room for receiving a irradiated object, wherein the beam shaping assembly rotates around the axis of the tube.

Provided are a method for measuring dose distribution in a mixed radiation field of neutrons and gamma rays, and a method for measuring beam uniformity of a mixed radiation field of neutrons and gamma rays. The planar dose measuring method includes: a step of obtaining a total dose of neutrons and gamma rays by measuring with a dosimeter; and a step of analyzing a neutron dose. The method may effectively measure the doses of neutrons and gamma rays, may be applied to beam measurement and treatment plan validation, and thus improve the quality of treatment.

Radiation dose measuring method

Provided is a method for preparing L-BPA, which includes steps of: 

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Jiangsu, China

Yuanhao Liu