University of Texas System

Yuanfen Wei

Allan R Brasier

Thomas G Wood

Tao Hai

Disclosed are isolated IKK&#x3b3;&#x394;; isolated nucleic acid molecules encoding IKK&#x3b3;&#x394;; expression vectors and cells which contain such nucleic acid molecules; oligonucleotides which are complementary to at least a portion of nucleic acid molecules encoding IKK&#x3b3;&#x394; but which are not complementary to any portion of nucleic acid molecules encoding wild type IKK&#x3b3;; antibodies which are specific for IKK&#x3b3;&#x394;; DNA and RNA oligomers, optionally in labeled or enzymatically active form, which are capable of selectively hybridizing to nucleic acid molecules encoding IKK&#x3b3;&#x394;; and DNA and RNA oligomers, optionally in labeled or enzymatically active form, which are capable of selectively hybridizing to nucleic acid molecules encoding IKK&#x3b3;&#x394; but which do not hybridize with nucleic acid molecules encoding wild type IKK&#x3b3;. Methods for using these materials to inhibit formation of IKK&#x3b3;&#x394;-containing IKK, to inhibit NF-&#x3ba;B activation, and to treat or prevent inflammation are also disclosed.

Growing community of inventors

Galveston, TX, United States of America

Yuanfen Wei