Landmark Graphics Corporation

Pfizer Corporation

Halliburton Energy Services, Inc.

Yuan Zhang

Robello Samuel

Bethany Lyn Kormos

Matthew Richard Reese

David Andrew Griffith

Kevin James Filipski

Luis Angel Martinez-Alsina

Rachel Jane Roth Flach

Leanne Marie Buzon

Samit Kumar Bhattacharya

Russell Alan Miller

Michael Aaron Brodney

Patrick Robert Verhoest

Christopher Ryan Butler

Jotham Wadsworth Coe

Christopher John Helal

Travis T Wager

Thomas Allen Chappie

Jaclyn Louise Henderson

Zhengchun Liu

Aniket

Joseph Scott Warmus

Martin Youngjin Pettersson

Brian Kenneth Raymer

Antonia Friederike Stepan

Paul Galatsis

Karen Jean Coffman

Michelle Renee Garnsey

Jinshan Michael Chen

Ravi G Kurumbail

Colin Richard Rose

Vakkeyil Naveen Nair

Kevin Francis Deboyace

Luis Angel Martinez Alsina

Shenping Liu

Kiyoyuki Omoto

Described herein are compounds of Formula I, wherein the variables are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, diabetes, kidney disease, NASH and heart failure.

BCKDK inhibitors and/or degraders

The embodiments include systems and methods to determine torque and drag of a string. A method includes analyzing a plurality of continuous segments of a string deployed in a wellbore, and determining a deflection of the plurality of continuous segments from a node of the string and a tortuosity deflection of the wellbore. In response to a determination that deflection of the plurality of continuous segments from the node of the string is greater than the tortuosity deflection of the wellbore, the method includes applying a soft string model to determine a torque and a drag of the string. In response to a determination that deflection of the plurality of continuous segments from the node of the string is not greater than the tortuosity deflection of the wellbore, the method includes applying a stiff string model to determine a torque and a drag of the string.

Systems and methods to determine torque and drag of a downhole string

The disclosed embodiments include well operation evaluation systems and methods to analyze a broomstick chart of a well operation. The method includes receiving data indicative of a well operation involving deploying a conveyance to a predetermined location. The method also includes determining one or more conditions that impact deployment of the conveyance to the predetermined location. The method further includes determining a likelihood of occurrence of the one or more conditions. The method further includes determining one or more operations which, when performed by one or more tools used during the well operation, overcome the one or more conditions.

Conveyance deployment systems and methods to deploy conveyances

The disclosure presents apparatuses and systems to reduce drag and friction forces on a drill string located downhole a borehole. The drill string can have two or more movement isolators to allow a movement sensitive tool to be movement isolated from other portions of the drill string that have powered movement. The other drill string portions can be powered by a surface equipment or by a downhole movement motor attached to the drill string, such as a rotational mud motor, an agitator, a jar motor, or a rotary steerable. Portions of the drill string located further downhole than the movement sensitive tool can utilize a movement motor attached to the drill string to provide movement to reduce drag and friction force where the movement isolators can reduce the movement force experienced by the movement sensitive tool.

Multiple swivels and rotation motor system

A method for controlling computerized operations related to a wellbore comprises drilling the wellbore in a subsurface formation with a drill string including a drill bit. The method comprises acquiring a plurality of drilling parameters while drilling the wellbore. The method comprises determining, based on the plurality of drilling parameters, solids properties for solids forming a cutting plug up hole of the drill bit. The method comprises determining a length of the cutting plug based on the solids properties. The method comprises determining a cutting plug friction force based on the cutting plug length and a pressure differential across the cutting plug. The method comprises performing a drilling operation based on the cutting plug friction force.

Friction for cutting plug

An agitator for vibrating a drill string includes an agitator housing, a rotor and an agitation mass. The drill string has a central axis. The rotor is coupled to the agitator housing and being rotatable about an agitator axis. The agitation mass is coupled to the rotor and is rotatable about the agitator axis. During rotation, a center of mass of the agitation mass is spaced apart from the agitator axis to cause deflection of the agitator axis relative to the central axis to produce vibration in the drill string.

Agitator for use with a drill string

Described herein are compounds of Formula I, wherein R, R, and Rare defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart failure.

BCKDK inhibitors

A method for calculating wellbore casing wear is provided that includes determining a wellbore boundary for an open hole wellbore segment, calculating a casing shape within the open hole wellbore segment based on one or more casing attributes, determining whether or not the casing shape exceeds the wellbore boundary, calculating casing wear based on the boundary of the open hole wellbore segment if the casing shape is determined to exceed the wellbore boundary, otherwise calculating the casing wear parameter based on the casing shape if the casing shape is determined not to exceed the wellbore boundary, and storing the casing wear parameter on a computer readable medium.

Casing wear calculation

A method includes comparing a natural frequency of a tubular with a frequency of each of at least two pulse generating devices positioned adjacent each other on the tubular, the tubular and the at least two pulse generating devices comprising an energy system; adjusting the frequency of at least one of the at least two pulse generating devices when the frequency is equal to the natural frequency of the tubular and obtaining an adjusted frequency different from the natural frequency; calculating an energy distribution in the energy system based on the natural frequency and the adjusted frequency of the at least one of the at least two pulse generating devices; and determining a new location on the tubular for positioning one or more of the at least two pulse generating devices such that energy introduced into the energy system is less than energy dissipated from the energy system.

Predicting damage to wellbore tubulars due to multiple pulse generating devices

The present invention provides novel imidazo[4,5-c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof I wherein R, Rand Rare as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy. 

Imidazo[4,5-C]quinoline derivatives as LRRK2 inhibitors

Systems and methods for detecting a gas kick within a wellbore are provided. The system includes a rotatable tool including one or more acceleration sensors and/or oscillators. The method includes rotating the rotatable tool in contact with fluid inside the wellbore and detecting changes in rotational velocity of the rotatable tool to detect the gas kick. In other aspects, the method includes detecting a change in density of the fluid within the wellbore by at least one or more pressure waves to determine the gas kick within the wellbore.

Systems and methods for detecting kick and well flow

A method comprising determining a property of a first section of drill pipe that is to connect a first agitator to a second agitator in a bottom hole assembly of a drill string, determining a distance between the first agitator and the second agitator based, at least in part, on the property of the first section of drill pipe, positioning the first agitator in the bottom hole assembly of the drill string, and positioning the second agitator in the bottom hole assembly of the drill string relative to the first agitator based, at least in part, on the distance.

Drillstring with a bottom hole assembly having multiple agitators

A method includes determining a first geometric parameter of an elastic component based on a second geometric parameter of the elastic component, wherein the elastic component is part of a bottomhole assembly having a bit and an eccentering mechanism operating on the elastic component. The method also includes determining a length difference of the elastic component based on the first geometric parameter, the second geometric parameter, and a stiffness factor of the elastic component. The method also includes determining a borehole curvature based on a sum of a bit tilt angle and a force-based side-cutting angle, wherein the force-based side-cutting angle is based on the length difference of the elastic component. The method also includes determining a setting of the eccentering mechanism based on the borehole curvature.

Directional tendency predictors for rotary steerable systems

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Missouri City, TX, United States of America

Yuan Zhang