Other

Chinese Academy of Medical Sciences

Jiangsu Micromedmark Biotech Co., Ltd.

China Parmaceutical University

Yuan Yin

Ying Liu

Decai Li

Fei Guo

XiaoHong Jia

Weifeng Huang

Yongjian Li

ShuangFu Suo

Xiangfeng Liu

Zixi Wang

Chenyu Zhang

Ke Zeng

Junfeng Zhang

Dayong Zhang

Chengjuan Chen

Tiantai Zhang

Xing Cai

Runan Yu

Lei Shu

A medicament with excellent JAK kinase (Janus Kinase) inhibitory activity can be used to prevent, treat and/or improve an autoimmune disease (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus and the like). The present invention also provides a pharmaceutically acceptable composition containing the compound and a method for preparing these compounds.

Preparation for 6-amino-1H-pyrazolo[3,4-d]pyrimidine-based JAK kinase inhibitor and application thereof

An intelligent regulation system for a mechanical seal, the system comprising: a monitoring device for measuring a signal correlated with a seal in real time; a control device, comprising a state determination module, a feasible region analysis module, an evaluation module and an optimizing module, wherein the state determination module unscrambles the signal obtained by the monitoring device to estimate the state of the seal; the feasible region analysis module determines, according to a current state, a state that the seal can reach by means of the regulating effect of a regulating device; the evaluation module evaluates a value for the state of the seal; and the optimizing module searches a feasible region, where the seal is regulated, for a regulating method with a relatively high value to the greatest extent, and accordingly sends an instruction to the regulating device; and the regulating device for actively applying an action to the seal according to the instruction given by the control device.

Intelligent regulation system and method for mechanical seal

A real-time monitoring and analysis method for a mechanical seal. In the method, an acoustic emission signal generated by a friction pair at a mechanical seal end surface is measured; a specific acoustic source generate signals on a plurality of specific frequency bands on an acoustic scale. In a seal operating process motion causes the acoustic emission signal to change on a dynamic time scale equivalent to a period of rotation. In a long-term seal service process, cumulative performance changes occur on a service time scale due to running-in, wear, and/or aging of elastic elements; for this feature, the long-term change process of the acoustic emission signal needs to be considered. Analysis is performed, on multiple scales, in combination with auxiliary information and with determined physical characterization quantities passed to scales of longer time, thereby determining the real-time working state of the seal and providing a performance change expectation of the seal. In an embodiment, the acoustic scale transfers frictional power consumption, maximum contact depth and leakage rate to the dynamic scale, and the dynamic scale transfers a wear rate to the service scale, while part of the auxiliary information of the acoustic scale analysis may come from the results of the service scale analysis.

Multi-scale real-time acoustic emission monitoring and analysis method for mechanical seal

Provided is a use of miRNA-214 inhibitor in inhibiting regulatory T cells (Treg cells). The microRNA-214 (miRNA-214) can promote Treg cells, and can assist tumors in immune escape. The experiments demonstrates that the inhibition of miRNA-214 can inhibit the growth of Treg cells, thus inhibiting the growth of tumors. Therefore, miRNA-214 can be used for developing an anti-tumour drug or a drug inhibiting immune response hyperactivity.

Use of miRNA-214 inhibitor in inhibiting regulatory cells

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Beijing, China

Yuan Yin