Coopervision International Holding Company, LP

Seagate Technology Incorporated

Chemocentryx, Inc.

Coopervision International Limited

Yuan Xu

Charlie Chen

Yuwen Liu

Ying Zheng

Arthur Back

Charles A Francis

Li Yao

Junhao Ge

Penglie Zhang

Wei Yu Chen

Manmohan Reddy Leleti

Yandong Li

Andrew M K Pennell

Ye Hong

Lianfa Li

John J Kim Wright

Koichi R Wago

Paul Richardson

Hiroyuki Ueyama

Wei Hu

Yibin Zeng

Kevin Lloyd Greenman

Hong Xue

David Shiao-Min Kuo

Justin Jia-Jen Hwu

Prasad Dande

Gene Gauzner

Mark M Gleason

Hongjin Qiu

Wei Chen

Andrew M Pennell

David S Kuo

Kim Yang Lee

Xiaomin Yang

ShuaiGang Xiao

Yuan Sun

Lei Wan

Xining Zhang

Shane Mao

John J Wright

John Kim J Wright

Francis A Charles Charles

HEMA-compatible siloxane monomers are described that can be used to manufacture contact lenses that combine the attributes of HEMA-based contact lenses with the high oxygen permeability of silicone hydrogel lenses. Optically clear silicone hydrogel contact lens can be manufactured that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising: a) at least 25 wt. % of at least one hydroxyalkyl methacrylate; and b) at least 20 wt. % of at least one HEMA-compatible polysiloxane.

Contact lenses made with HEMA-compatible polysiloxane macromers

A method for nano-patterning includes imprinting features in a resist with an imprint mold to form one or more topographic surface patterns on the imprinted resist. A block copolymer ('BCP') material is deposited on the imprinted resist, wherein a molecular dimension Lof the BCP material correlates by an integer multiple to a spacing dimension of the one or more topographic surface patterns on the imprinted resist. The deposited BCP is annealed and at least a portion of the annealed BCP is removed, forming a template having discrete domains.

Hybrid-guided block copolymer assembly

Optically clear silicone hydrogel contact lenses are described that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising at least 25 wt. % of at least one hydroxyalkyl methacrylate; and at least 20 wt. % of at least one HEMA-compatible bifunctional polysiloxane comprising at least 6 siloxane groups and having an HLB value of at least 5 and/or a hydroxyl group content of at least 1 wt. %.

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Azaindazole compounds and methods of use

Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer, or at least one hydrophilic vinyl ether-containing monomer, or both, wherein, when the at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, and when the at least one hydrophilic vinyl ether-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Silicone hydrogel contact lenses

Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent. The contact lenses have ophthalmically-acceptable ionoflux values and surface wettability, and can be manufactured without the use of volatile organic solvents.

Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one hydrophilic vinyl amide-containing monomer, at least one acrylate-containing siloxane monomer, and at least one hydrophilic vinyl ether-containing monomer. The contact lenses have ophthalmically-acceptable surface wettability and can be manufactured without the use of volatile organic solvents.

Silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including 30-60 unit parts by weight of a hydrophilic monomer(s) having one N-vinyl group, 10 to 50 unit parts by weight of 2-hydroxyethyl methacrylate (HEMA), and a first siloxane monomer component comprising a siloxane monomer of formula (1) as described herein or a siloxane monomer of formula (2) as described herein or a siloxane monomer of formula (3) as described herein or any combination thereof, where the total amount of siloxane monomer(s) present in the polymerizable composition is from 15 to 40 unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): 

A planarization process may planarize a media disk that has data trenches between data features and larger servo trenches between servo features. A filler material layer is deposited on the media disk and provides step coverage of the trenches. The filler material has data recesses over the data trenches and servo recesses over the servo trenches that must be removed to produce a planar media surface. A first planarization process is used to remove the data recesses and a second planarization process is used to remove the servo recesses.

Magnetic device with different planarization areas

A method for preparing a polymerizable monomer-dye compound is provided in which a monomer, a reactive dye, and base are combined under substantially anhydrous reaction conditions to form the polymerizable monomer-dye compound, wherein the monomer comprises a pendant reactive group that covalently links to the reactive dye to form the monomer-dye compound.

Reactive dyes for contact lenses

Patterned substrates templates are provided, as well as methods comprising a combination of lithography and self-assembly techniques. The patterned substrates may comprise first and second patterns.

Block copolymer assembly methods and patterns formed thereby

Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): 

Wettable silicone hydrogel contact lenses

Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

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Fremont, CA, United States of America

Yuan Xu