Scinopharm Taiwan, Ltd.

Scinopharm Singapore Pte Ltd.

Scniopharm Singapore Pte Ltd.

Yuan-Xiu Liao

Tsung-Yu Hsiao

Wen-Li Shih

Shang-Hong Chen

Li-Ting Wang

Shu-Ping Chen

Meng-Fen Ho

Lung-Huang Kuo

Chia-Ning Lin

Yu-Li Lin

Yung-Hung Chang

Yuan-Chang Huang

Hsin-Chang Tseng

Jiunn-Cheh Guo

The present invention provides improved processes for the preparation of elagolix and intermediates thereof. The intermediate of formula VII is achieved by a coupling reaction of a compound of formula V and a N-benzylidene protected compound of formula IV: The present invention is suitable for a large-scale production, avoiding the use of potential genotoxic substances and can be performed under mild conditions.

Process for preparing elagolix sodium and intermediates thereof

Crystalline form S1 of irinotecan free base characterized by a powder X-ray diffraction pattern with peaks at about 8.7&#xb1;0.2, 13.1&#xb1;0.2, 14.5&#xb1;0.2, 17.4&#xb1;0.2, 18.4&#xb1;0.2, 20.9&#xb1;0.2, 24.0&#xb1;0.2 and 27.5&#xb1;0.2 degrees two-theta degrees two-theta, and crystalline form S2 of irinotecan free base characterized by a powder X-ray diffraction pattern with peaks at about 7.1&#xb1;0.2, 10.6&#xb1;0.2, 12.4&#xb1;0.2, 20.6&#xb1;0.2, 21.6&#xb1;0.2 and 24.2&#xb1;0.2 degrees two-theta.

Polymorphism for irinotecan free base

The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at a reaction pH of no more than about 9.0. In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.

Process for the production of Fondaparinux sodium

The present invention provides a process for the efficient preparation of enzalutamide.

Process for preparing enzalutamide

The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5  In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.

Process for the production of fondaparinux sodium

New anhydrous crystalline form of docetaxel and process of making anhydrous docetaxel and docetaxel trihydrate are provided.

Crystalline forms of docetaxel and process for preparation thereof

Anbydrous crystalline form of docetaxel and process of making anhydrous docetaxel and docetaxel trihydrate are provided.

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Tainan, Taiwan

Yuan-Xiu Liao