Hilti Aktiengesellschaft

Chongqing University

Shanghai University

Yafei (shanghai) Biopharmaceutical Co., Ltd.

China Triumph International Engineering Co., Ltd.

Acleap Power Inc.

Yafei Shanghai Biology Medicine Science & Technology Co. Ltd.

Ucloud Tech Co., Ltd

Yafei Shanghai Biolog Medicine Science & Technology Co. Ltd.

Yuan Liu

Cheng Liu

Jun Luo

Yan Peng

Tobias Koeniger

Huayan Pu

Shaorong Xie

Zhijiang Xie

Xiaomao Li

Jiajia Xie

Zhou Su

Chen Liu

Shou Peng

Christian Scheidel

Rui Liu

Heiko Aupperle

Ming Cheng

Hengyu Li

You Chen

Yifeng Sun

Xing Yi

Julian Winckler

Lishen Zhou

Haiyang Wang

Shukai Wu

Juyan Zhang

Zhaokai Si

Embodiments of the present disclosure relate to a circuit for limiting duty cycle for a DC switching power supply. The circuit includes: a timing module and a switch control module. The timing module is configured to cause the variable output voltage to increase to a voltage threshold within a time shorter than a duration time of the first level of the period. The switch control module is configured to: in a period having the duty cycle greater than the maximum limit duty cycle, output a signal enabling the switch to be turned on before the variable output voltage increases to the voltage threshold, and output a signal enabling the switch to be turned off independently of the pulse signal after the variable output voltage increases to the voltage threshold. The circuit enables the duty cycle of the switch not to be excessively large during the transition phase.

Circuit for limiting duty cycle and DC switching power supply with constant output

A method and system for controlling multi-unmanned surface vessel (USV) collaborative search are disclosed which relate to the technical field of the marine intelligent USV collaborative operation. The method includes determining a task region of a USV team; determining environmental perception information corresponding to each of the USVs at the current moment according to the task region and the probability graph mode; inputting the environmental perception information corresponding to each of the USVs at the current moment into the corresponding target search strategy output model respectively to obtain an execution action of each of the USVs at the next moment; sending the execution action of each of the USVs at the next moment to a corresponding USV execution structure to search for underwater targets within the task region. The target search strategy output model is obtained by training based on a training sample and a DDQN network structure.

Method and system for controlling multi-unmanned surface vessel collaborative search

A control method and system for collaborative interception by multiple unmanned surface vessels are provided. The method includes obtaining task environment information of each unmanned surface vessel in an unmanned surface vessel group at a current moment, estimating interception point information of the intruding target at the current moment by using a Kalman filter according to the task environment information of the unmanned surface vessels at the current moment, determining process state information of each unmanned surface vessel at the current moment, inputting the process state information of each unmanned surface vessel at the current moment into a corresponding intruding target interception policy output model respectively to obtain an execution action of each unmanned surface vessel at a next moment to intercept the intruding target. The application can intercept the intruding target accurately.

Control method and system for collaborative interception by multiple unmanned surface vessels

An isothermal drop speed cooling method and an apparatus for same. A glass ribbon carried with glass passes through the forced convection area of the glass annealing lehr, and the glass ribbon is moving while the glass is being air-cooled in the forced convection area. The glass is air-cooled by different air volume according to the temperature of the glass, so that the glass is allowed to be cooled at isothermal drop speed during the moving process of the glass. According to the cooling method and apparatus, the specification size of the opening section of multi-row air nozzles longitudinally arranged is increased along the moving direction of the glass ribbon, so that the cooling air volume from the front to the rear can be gradually increased, thereby allowing the temperature drop speed of a glass plate to be uniform from the front to the rear.

Isothermal drop speed cooling method of forced convection area for lehr and the apparatus thereof

Doxorubicin derivatives for targeted activation by Legumain, its preparation method and use. The doxorubicin derivatives are obtained by condensation between the amino group of compound A and the carboxyl group of compound B and have the following structure: compounds A and B have the following structures, respectively: wherein Rin compound B is Leu or absent; Ris any one amino acid selected from the group consisting of Ala and Thr; Ris any one amino acid selected from the group consisting of Ala, Thr and Asn; Ris wherein n=1-20; or wherein Ris substituted or unsubstituted, linear or branched, saturated or unsaturated C1-C20 fatty hydrocarbon, or substituted or unsubstituted C6-C20 aromatic hydrocarbon. The doxorubicin derivatives of the present invention are specifically tumor-targeted and have a long in vivo metabolic half-life, as compared with doxorubicin. They exhibit an efficient and safe anti-tumor effect and could be used to prepare an anti-tumor drug.

Immune-stimulating soluble doxorubicin-conjugated complex

Disclosed are molecularly targeted and activated kinase inhibitors and use thereof. Specifically, a compound represented by the following formula A or a pharmaceutically acceptable salt thereof, wherein X is a polar and a non-polar uncharged amino acid such as alanine, proline or threonine; A is alanine; N is asparagine; PABC is &#x2014;NH-phenyl-CH2-O&#x2014;; and Z is a drug molecule; wherein the lactobionic acid residue, XAN and PABC are linked to each other by an amide bond; PABC is bonded to Z by an ester group, i.e., &#x2014;OC(O)&#x2014;.

Preparation and use of molecular site targeted and activated kinase inhibitor

The present disclosure provides a data processing method, a data processing apparatus, a data processing system and a non-volatile storage medium. The method comprises: an acquisition step of acquiring data from at least one data provider and acquiring an algorithm from an algorithm provider via an access gateway; a calculation step of calculating the data according to the algorithm, so as to obtain a calculation result; and a review step of reviewing the calculation result by the at least one data provider via the access gateway, so as to determine whether the calculation result is allowed to be output to at least one result data owner.

Data processing method, apparatus, system, and storage medium

Provided is an anticancer compound including a cleavable linker specifically activated in a tumor microenvironment, and use thereof. The anticancer compound is represented by the following formula, wherein, Ris a normal functional group or a protection group; Ris Ala, Thr, Val or Ile; Ris Ala, Val or Asn; Ris a drug group linked via a hydroxyl group or an amino group; and the general formula of the drug is RH. The anticancer compound is only activated at a local portion of a tumor, thus avoiding the defect of immune system damage of a traditional chemotherapeutic drug, and promoting tumor immunization by removing a tumor immunosuppression cell. The anticancer compound or pharmaceutical composition thereof is jointly used with immunotherapy, thus improving the effect of treating the tumor, and effectively inhibiting tumor metastasis and osseous metastasis. 

Small molecule conjugates specifically activated in tumor microenvironment for targeting and use thereof

Combination hammer drill

The present invention discloses doxorubicin derivatives for targeted activation by Legumain, its preparation method and use. The doxorubicin derivatives are obtained by condensation between the amino group of compound A and the carboxyl group of compound B and have the following structure: compounds A and B have the following structures, respectively: wherein Rin compound B is Len or absent; Ris any one amino acid selected from the group consisting of Ala and Thr; Ris any one amino acid selected from the group consisting of Ala, Thr and Asn; Ris wherein n=1-20; or wherein Ris substituted or unsubstituted, linear or branched, saturated or unsaturated C1-C20 fatty hydrocarbon, or substituted or unsubstituted C6-C20 aromatic hydrocarbon. The doxorubicin derivatives of the present invention are specifically tumor-targeted and have a long in vivo metabolic half-life, as compared with doxorubicin. They exhibit an efficient and safe anti-tumor effect and could be used to prepare an anti-tumor drug.

Legumain activated doxorubicin derivative as well as preparation method and application thereof

Rotation laser

Growing community of inventors

Shanghai, China

Yuan Liu