Bemis Company, Inc.

Amcor Flexibles North America, Inc.

Yuan Liu

Rishabh Jain

Xiangke Shi

Lyndsey A McMillan

Christopher L Osborn

Chris Osborn

Jennifer L Riis

Jennifer Riis

Ryan A Michaud

Lyndsey Mcmillan

A film for packaging a product that has a pharmaceutical active agent includes a product-contacting sealing layer. The product contacting layer includes at least 90 wt. % of an ethylene norbornene copolymer having a glass transition temperature in a range from 50° C. to 110° C. The pharmaceutical active agent comprises a Hansen Solubility Parameter for the product-contacting sealing layer of 0.5 or greater.

Anti-scalping pharmaceutical packaging film

A multilayer flexible film for packaging a transdermal patch product comprising a pharmaceutical active agent comprises: a product-contacting sealing layer comprising a co-polyester having a surface energy of at least 50 dyne/cm; and one or more layers above the product-contacting sealing layer. The pharmaceutical active agent may comprise nicotine. An average adhesion force to peel the transdermal patch from the product-contacting sealing layer may be less than 100 g/inch (39.37 g/cm).

Transdermal patch packaging film

Heat-seal condition indicating packages include a first sealing substrate comprising a leuco dye and a second sealing substrate comprising a leuco dye developer. The packages may optionally include a leuco dye sensitizer which dissolves both the leuco dye and the leuco dye developer when melted. The packages further include a heat-seal produced between the first sealing substrate and the second seating substrate. The heat-seal comprises a reaction product of the leuco dye and the leuco dye developer. The reaction product may be colored, which may provide the heat-seal with a detectable optical characteristic. A magnitude of the optical characteristic may be proportion to the strength of the seal between the first and second seating substrates.

Package for indicating heat-seal condition

A film for packaging a product that has a pharmaceutical active agent includes a product-contacting sealing layer. The product contacting layer includes at least 90 wt. % of an ethylene norbornene copolymer having a glass transition temperature in a range from 50&#xb0; C. to 110&#xb0; C. The pharmaceutical active agent comprises a Hansen Solubility Parameter for the product-contacting sealing layer of 0.5 or greater.

The present invention is directed to heat-seal condition indicating packages having a first sealing substrate comprising a leuco dye and a second sealing substrate comprising a leuco dye developer, and a leuco dye sensitizer which dissolves both the leuco dye and the leuco dye developer when melted which is disposed in or on the surface of either the first or second sealing substrata or disposed in or on the surface of both the first and second sealing substrates. The packages of the present invention further include a heat-seal produced between the first sealing substrate and the second sealing substrate which comprises a heat-seal defect-free state which produces a visible color change within the heat-seal after heat sealing, and/or a heat-seal defect state which produces no visible color change within the heat-seal after heat sealing.

Growing community of inventors

Neenah, WI, United States of America

Yuan Liu