Medical and Pharmaceutical Industry Technology and Development Center

Yuan-Ling Ku

Yu-Hsuan Lin

Feng-Nien Ko

Yueh-Chu Chen

Chien-Jen Shih

Chih-Sheng Hung

Ying-Yu Kuo

Che-Yi Lin

Hsiao-Chu Huang

Chun-Hung Kuo

Chien-Chang Wu

Yi-Chen Lin

Cheng-Po Huang

Shih-Tsun Liang

Jui-Ching Chen

Liang-Hua Chen

Disclosed herein is the use of an extract from an Aster species for the preparation of a medicament for the treatment of opioid-induced constipation. The extract is extracted from fresh and/or dried roots and rhizomes of a Tatarian aster () plant, in which the extraction uses water or 40-95% (v/v) ethanol as an extractant to obtain an extraction mixture. In some embodiments, the extraction mixture is then eluted with water followed by at least one eluent.

Use of aster extract in the treatment of opioid-induced constipation

An antitussive composition is provided. A pharmaceutical composition for relieving, preventing and/or treating a cough includes a sufficient amount of thePoir extract as an active component. The effectivePoir extract is prepared by extracting the root-bark of thePoir with water, ethanol, acetone, ethyl acetate, or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.

Antitussive composition and method for making the same

An extract prepared from the root barks ofPoir. and its use as an anti-bacteria agent, and use of a compound Kuwanon H having the following formula (I) separated from the extract as an anti-bacteria agent: 

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Yuan-Ling Ku