Allergan, Inc.

Beckman Coulter, Inc.

Allergan Sales, Inc.

Other

Yuan Lin

Roshantha A Chandraratna

Richard L Beard

Min Teng

Vidyasagar Pradeep Vuligonda

Alan T Johnson

Tien T Duong

Josephine M Michael

Michael L Bell

Stephen L Pentoney, Jr

Tsong-Tseh Tsay

Gene G-y Shen

Fluorescent labeled reporter compounds having a modified cyanine dye that is coupled to a nucleotide derivative through a linker are disclosed. The compounds are useful for nucleic acid sequence analysis. The fluorescent labeled reporter compounds are ring-locked cyanine dyes that are coupled to a nucleotide derivative, such as a modified DNA base, through a linker. These fluorescent labeled reporter compounds can be used as DNA chain-terminators in DNA synthesis to generate DNA fragments that are fluorescently-labeled at the 3'-terminal end of the DNA fragment.

Fluorescent labeled nucleotide derivatives

An analyte detection system utilizing a combination of fluorescent labels for labeling particles and an analyte specific fluorescent analyte detection dye. The particles contain a combination of fluorescent labels for coding the particles and an analyte specific fluorescent dye. The particles can be used to identify and quantify analytes in an analytical sample by reaction of the analytical sample with the particles. An analytical device can identify the particles according to the combination of fluorescent labels. The device can then correlate the identified particle with the analyte specific fluorescent analyte detection dye. Multiple subpopulations of particles can be used to identify and quantify multi-analytes in a single analytical sample. Near infrared (NIR) fluorescent labels useful in the detection system are also provided.

Analyte detection system

Compounds of the formulawhere the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.

O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity

O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity

Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.

O-or S-substituted tetrahydronaphthalene derivatives having retinoid

Alkylidene substituted tetrahydronaphthalene derivatives having retinoid

Tetrahydronaphthalene derivatives substituted in the 8 position with

O-  or S-  substituted tetrahydronaphthalene derivatives having retinoid

A compound of the formula ##STR1## wherein all variables are as defined in the specification having retinoid-like activity.

Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group

Compounds of Formula I ##STR1## wherein the symbols are as defined in the specification.

Compounds of the formula ##STR1## wherein the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.19, Y, A, B, m and o have the meaning described in the specification have retinoid like biological activity.

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Walnut, CA, United States of America

Yuan Lin