Megapro Biomedical Co., Ltd.

Industrial Technology Research Institute

Yuan-Hung Hsu

Shian-Jy Jassy Wang

Chih-Lung Chen

Wen-Yuan Hsieh

Ming-Cheng Wei

Chia-Wen Huang

Pei Kan

Yuan-Chia Chang

Jhih-Yun Jian

Tsai-Yu Lin

Chin-Fu Chen

Ming-Fa Hsieh

Hsuen-Tseng Chang

Jui-Mei Lu

Su-Yo Lin

Shin-Yi Huang

Hsin Jung Huang

Chen-Hsuan Lin

Chu-Chun Hsueh

A biocompatible magnetic material containing an iron oxide nanoparticle and one or more biocompatible polymers, each having formula (I) below, covalently bonded to the iron oxide nanoparticle: in which each of variables R, L, x, and y is defined herein, the biocompatible magnetic material contains 4-15% Fe(II) ions relative to the total iron ions. Also disclosed in a method of preparing the biocompatible magnetic material.

Biocompatible magnetic materials

A pharmaceutical composition containing a mixed polymeric micelle and a drug enclosed in the micelle, in which the mixed polymeric micelle, 1 to 1000 nm in size, includes an amphiphilic block copolymer and a lipopolymer. Also disclosed are preparation of the pharmaceutical composition and use thereof for treating cancer.

Pharmaceutical compositions containing mixed polymeric micelles

A method of treating a condition related to iron deficiency. The method includes steps of identifying a patient having a condition related to iron deficiency and administering an effective amount of biocompatible iron oxide nanoparticles to the patient. The biocompatible iron oxide nanoparticles each contains an iron oxide core that is covered by one or more biocompatible polymers, each of which has a polyethylene glycol group, a silane group, and a linker linking, via a covalent bond, the polyethylene glycol group and the silane group.

Method of treating iron deficiency

This present disclosure relates to pharmaceutical compositions for treating tumors using a polymeric micelle encapsulating an anti-tumor drug. The polymeric micelle comprises block copolymers comprising at least one hydrophilic block, at least one hydrophobic block, and at least one zwitterion. The present disclosure also relates to methods of enhancing the solubility of such drugs, methods of increasing the blood circulating time of such drugs, and methods of delivering such drugs to one or more solid tumors.

Drug composition for treating tumor with polymeric micelle encapsulating anti-neoplastic

An amphiphilic block copolymer. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nano particle and carrier comprising the amhpiphilic block copolymer for delivery of water-insoluble drugs, growth factors, genes, or cosmetic substances.

Amphiphilic block copolymers and nano particles comprising the same

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Hsinchu, Taiwan

Yuan-Hung Hsu