General Electric Company

Ge Homeland Protection, Inc.

Morpho Detection, Inc.

Yuan-Hsiang Lee

Frank John Mondello

Michael Craig Burrell

Anis Zribi

Wei-Cheng Tian

Tao Deng

Min-Yi Shih

William Joseph McGann

Andrew David Pris

Tracy Lynn Paxon

William Scott Sutherland

Kenneth Ribeiro

Patrick Ronald Engel

A method for increasing a spectroscopic signal in a biological assay is provided. The method includes forming a suspension of magnetically attractable particles. The method also includes introducing a first magnetic field at a first location to draw the magnetically attractable particles towards the first location and form a first agglomeration. The method also includes removing the first magnetic field. The method further includes introducing a second magnetic field at a second location to draw the first agglomeration towards the second location and form a second agglomeration. The method further includes focusing an excitation source on the second agglomeration formed at the second location.

System and method for increasing spectroscopic signal

An optofluidic device is provided. The device includes a cladding region having a first refractive index, and a channel defined by the cladding region such that the cladding region forms an inner surface or an interface of the channel. The channel is configured to house one or more of a liquid, a solid, a gas, a colloidal, or a suspension sample, wherein the sample has a second refractive index, where the channel is configured to guide radiation, and where the first refractive index is lower than the second refractive index.

Optofluidic devices and methods of using the same

A lateral flow device is disclosed. The lateral flow device includes a substrate having a flow path and a detection zone disposed along the flow path. The detection zone includes an immobilized target-binding moiety directed against a target of a Raman-active complex. Also disclosed is a method of conducting a lateral flow assay and detection system. The method includes i) defining a flow path having a detection zone; ii) flowing a sample down the flow path; and iii) immobilizing a Raman-active complex if present, at the detection zone. The sample includes a Raman-active complex or a Raman-active tag.

Raman-active lateral flow device and methods of detection

An apparatus for generating a Raman signal of a test sample is disclosed. The apparatus includes a first optical path, a second optical path, a first station, and a second station. The first optical path is adapted for coupling with a radiation source that produces a test beam at the first optical path. The first station is responsive to the test beam and is adapted to house a test standard. The second station is responsive to the test beam and is adapted to house the test sample. In response to the test beam, Raman radiation from the test standard and the test sample are combined and directed to the second optical path, which is adapted for coupling with a spectrometer and a detector for producing a Raman spectrum of the test sample.

Apparatus and method for producing a calibrated Raman spectrum

A cargo inspection apparatus for the inspection of an analyte carried by a medium is disclosed. The apparatus includes a housing having an inlet allowing for entry of the medium and an outlet allowing for exit of the medium, and an adsorber disposed within the housing in fluid communication with the medium flow from the inlet to the outlet, the adsorber includes a substrate having disposed thereon a nanoparticle film. The nanoparticle film has nanoparticles having an average particle size of equal to or less than about 500 nanometers.

Cargo inspection apparatus having a nanoparticle film and method of use thereof

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Winchester, MA, United States of America

Yuan-Hsiang Lee