Neuboron Medtech Ltd.

Yuan-Hao Liu

Wei-Lin Chen

Pei-yi Lee

Ming-Chen Hsiao

Ming-Chuan Chang

Jing He

Wenyu Xu

Pei-Yi Lee

Jui-fen Chen

Fa-Zhi Yan

Wei-Hua Lu

Hong-feng Ji

Dong-chun Wang

A neutron capture therapy system and a target for a particle beam generating device, which may improve the heat dissipation performance of the target, reduce blistering and extend the service life of the target. The neutron capture therapy system includes a neutron generating device and a beam shaping assembly. The neutron generating device includes an accelerator and a target, and a charged particle beam generated by acceleration of the accelerator interacts with the target to generate a neutron beam. The target includes an acting layer, a backing layer and a heat dissipating structure, the acting layer interacts with the charged particle beam to generate the neutron beam, the backing layer supports the action layer, and the heat dissipating structure includes a tubular member composed of tubes arranged side by side.

Neutron capture therapy system and target for particle beam generating device

An animal irradiation system includes a radioactive source and an irradiation fixing apparatus having irradiated bodies. The radioactive source includes a beam outlet having a first central axis. Radioactive rays generated by the radioactive source exit from the beam outlet and irradiate the irradiated bodies. The radioactive rays define a main axis around the first central axis. The irradiation fixing apparatus includes a box body, which is divided into multiple accommodating chambers around a second central axis. Each accommodating chamber accommodates an irradiated body. Multiple first irradiation holes corresponding to the accommodating chambers are formed on the box body. The radioactive rays pass through the first irradiation holes and then irradiate the irradiated bodies. A maximum distance from an inner wall of each first irradiation hole to the first central axis is less than a minimum distance from an inner wall of the beam outlet to the first central axis.

Animal irradiation system

A process for analyzing elements and mass ratios of elements of a tissue includes approximating the tissue having unknown elements and mass ratios of the unknown elements thereof using the data of the medical image corresponding to a tissue having known elements and mass ratios of the known elements thereof. A method for establishing a geometric model based on a medical image includes: reading data of the medical image; defining a type of a tissue according to a conversion relationship between the data of the medical image and tissue types or according to the process; determining a quantity of tissue clusters of the tissue; defining a tissue density of the tissue by a conversion relationship between the data of the medical image and density values; establishing a 3D coding matrix with information about the tissue and the density; and generating the geometric model.

Method for analyzing elements and mass ratios of elements of tissue and method for establishing geometric model based on medical image

A neutron capture therapy system includes a neutron beam generating unit, an irradiation room configured to irradiate an irradiated body with a neutron beam, a preparation room configured to implement preparation work required to irradiate the irradiated body with the neutron beam, and an auxiliary positioner disposed in the irradiation room and/or the preparation room. The irradiation room includes a first shielding wall, a collimator is disposed on the first shielding wall for emitting the neutron beam, and the neutron beam is emitted from the collimator and defines a neutron beam axis. The auxiliary positioner includes a laser emitter that emits a laser beam to position the irradiated body, wherein the position of the laser emitter is selectable. Therefore, the irradiated body can be positioned in any case to implement precise irradiation.

Neutron capture therapy system

A method for measuring radiation intensity includes measuring the radiation intensity received by the protein in a radiation field based on degree of protein degradation in the radiation field, wherein the degree of degradation is a ratio of the molecular weight of the protein before and after irradiation. The measuring method is simple in operation, small in number of steps, small in error, and capable of measuring radiation doses of various radiation fields or even mixed radiation fields. Use of a biological dosimeter for measuring the radiation intensity by the method in a neutron capture therapy system can not only assess radiation contamination in the irradiation chamber, but also evaluate the neutron dose.

Method for measuring radiation intensity

A beam shaping assembly () used in a neutron capture system and capable of changing an irradiation range of a neutron beam. The beam shaping assembly includes: a beam inlet (), a target (), a moderator () adjoining the target (), a reflector () surrounding the moderator (), a thermal neutron absorber () adjoining the moderator (), a radiation shield () arranged inside the beam shaping assembly (), and a beam outlet (). The beam shaping assembly () further includes replacement components () that can be attached to and detached from the beam shaping assembly () to change the irradiation range of the neutron beam.

Disclosed is a moderator for moderating neutrons, including a substrate and a surface treatment layer or a dry inert gas layer or a vacuum layer coated on the surface of the substrate, wherein the substrate is prepared from a moderating material by a powder sintering device through a powder sintering process from powders or by compacting powders into a block, and the moderating material includes 40% to 100% by weight of aluminum fluoride; wherein the surface treatment layer is a hydrophobic material; and the surface treatment layer or the dry inert gas layer or the vacuum layer is used for isolating the substrate from the water in the environment in which the substrate is placed. The surface treated moderator can avoid the hygroscopic or deliquescence of the moderating material during use, improve the quality of the neutron source and prolong the service life.

Moderator for moderating neutrons

A neutron capture therapy system, including a beam shaping assembly and a vacuum tube. The beam shaping assembly includes a beam entrance, an accommodating cavity accommodating the vacuum tube, a moderator adjacent to an end of the accommodating cavity, a reflector surrounding the moderator, a radiation shield disposed in the beam shaping assembly, and a beam exit. A target is disposed at an end of the vacuum tube, nuclear reactions occur between the target and a charged particle beam entering through the beam entrance to generate neutrons. The moderator moderates the neutrons, the reflector guides deflected neutrons back to the moderator. The moderator at least includes two cylindrical moderating members with different outer diameters respectively, the moderator has a first end close to the beam entrance and a second end close to the beam exit, and the target is accommodated between the first end and the second end.

A neutron capture therapy system and a target for a particle beam generating device, which may improve the heat dissipation performance of the target, reduce blistering and extend the service life of the target. The neutron capture therapy system includes a neutron generating device and a beam shaping assembly. The neutron generating device includes an accelerator and a target, and a charged particle beam generated by acceleration of the accelerator interacts with the target to generate a neutron beam. The target includes an acting layer, a backing layer and a heat dissipating layer, the acting layer interacts with the charged particle beam to generate the neutron beam, the base layer supports the action layer, and the heat dissipating layer includes a tubular member composed of tubes arranged side by side.

In one aspect, a method for establishing a smooth geometric model based on data of a medical image includes: inputting or reading the data of the medical image; establishing a three-dimensional medical image voxel model based on the data of the medical image; smoothing the three-dimensional medical image voxel model; and establishing a three-dimensional voxel phantom tissue model based on the smoothed three-dimensional medical image voxel model. In another aspect, a method for establishing a smooth geometric model based on data of a medical image includes: inputting or reading the data of the medical image; establishing a three-dimensional voxel phantom tissue model based on the data of the medical image; and smoothing the three-dimensional voxel phantom tissue model.

Method for establishing smooth geometric model based on data of medical image

A medical image-based radiation shielding device and method thereof, which may form a targeted and highly accurate radiation shielding according to individual differences in patients, such as tumor location and size, thereby reduce or avoid radiation from a irradiation apparatus to normal tissues of patients. The shielding device includes a medical image scanning means for scanning an irradiated site of an irradiated subject and outputting medical image voxel data, a data processing and three-dimensional modeling means for establishing a three-dimensional phantom tissue model according to the medical image voxel data and establishing a three-dimensional shield model according to the three-dimensional phantom tissue model; a shield located between the irradiation apparatus and the irradiated site, wherein the shield is formed by printing the three-dimensional shield model data input to a 3D printer.

Medical image-based radiation shielding device and method thereof

Abeam shaping assembly for neutron capture therapy includes a beam inlet, a target having nuclear reaction with an incident proton beam from the beam inlet to produce neutrons forming a neutron beam, a moderator adjoining to the target, a reflector surrounding the moderator. The neutrons are moderated to epithermal neutron energies by the moderator, and part of the moderator disposed on the back of the target can be replaced so as to adjust the epithermal neutron energies. The reflector leads the neutrons deviated from the main axis back.

Beam shaping assembly for neutron capture therapy

The present disclosure provides a neutron capture therapy system including a beam shaping assembly. The beam shaping assembly includes a beam inlet; a neutron generator arranged into the beam shaping assembly, the neutron generator has nuclear reaction with an incident proton beam from the beam inlet to produce neutrons; a moderator adjacent to the neutron generator, the neutrons are moderated by the moderator to epithermal neutron energies; a reflector surrounding the neutron generator and the moderator, the reflector leads the deflected neutrons back to enhance epithermal neutron beam intensity; a beam outlet; and at least a movable member moving away from or close to the neutron generator, the movable member moves between a first position where the neutron generator is replaceable, and a second position where the neutron generator is irreplaceable. The neutron capture therapy system has a simple structure, and the neutron generator is easy to be replaced.

The present disclosure provides a neutron capture therapy system. The neutron capture therapy system includes an accelerator, the accelerator generates a charged particle beam; a neutron generator, the neutron generator generates a neutron beam after being irradiated by the charged particle beam; a beam shaping assembly, the beam shaping assembly includes a moderator and a reflector surrounds around the outer periphery of the moderator, the moderator moderates the neutrons generated by the neutron generator to a preset spectrum, and the reflector leads the deflected neutrons back to increase the neutron intensity within the preset spectrum; and a collimator, the collimator concentrates the neutrons generated by the neutron generator; the spectrum of the neutron beam is changed by changing the spectrum of the charged particle beam.

A neutron capture therapy system capable of eliminating amyloid &#x3b2;-protein includes a neutron capture therapy device and a compound capable of specifically binding to the amyloid &#x3b2;-protein having a nuclide with a large thermal neutron capture cross section. The neutron capture therapy device includes a neutron source, a beam shaping assembly and a collimator, the neutrons released by the neutron source pass through the beam shaping assembly and are slowed into a neutron beam within a certain energy range. The neutron beam irradiates the compound, and the energy generated by the reaction thereof can destroy the structure of the amyloid &#x3b2;-protein. The neutron capture therapy system can specifically eliminate the amyloid &#x3b2;-protein, and reduce the damage to the tissues surrounding the amyloid &#x3b2;-protein.

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Jiangsu, China

Yuan-Hao Liu