Industrial Technology Research Institute

Yuan-Chia Chang

Chin-Fu Chen

Pei Kan

Huey-Min Lai

Hsi-Hsin Shih

Tsai-Yu Lin

Yuan-Hung Hsu

Ming-Fa Hsieh

Chin-Chin Tsai

Kuang-Rong Lee

Chun-Jen Liao

Hsuen-Tseng Chang

Jui-Mei Lu

Kuei-Hung Wu

Yu-Yen Jan

Tsung-Yi Mou

Chu-Chun Hsueh

Hsuen-Tseng Cha'ng

Chun-Hui Chang

An amphiphilic block copolymer is disclosed. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nanoparticle and carrier including the amphiphilic block copolymer for delivery of water insoluble drugs, growth factors, genes, or water insoluble cosmetic substances.

Amphiphilic block copolymers and nanoparticles comprising the same

This present disclosure relates to pharmaceutical compositions for treating tumors using a polymeric micelle encapsulating an anti-tumor drug. The polymeric micelle comprises block copolymers comprising at least one hydrophilic block, at least one hydrophobic block, and at least one zwitterion. The present disclosure also relates to methods of enhancing the solubility of such drugs, methods of increasing the blood circulating time of such drugs, and methods of delivering such drugs to one or more solid tumors.

Drug composition for treating tumor with polymeric micelle encapsulating anti-neoplastic

An amphiphilic block copolymer. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nano particle and carrier comprising the amhpiphilic block copolymer for delivery of water-insoluble drugs, growth factors, genes, or cosmetic substances.

Amphiphilic block copolymers and nano particles comprising the same

A method of making a porous biodegradable polymer is disclosed, which comprises (a) placing a biodegradable polymer and a solvent in a chamber; (b) adding a supercritical fluid to the chamber and maintaining the chamber at a predetermined temperature for a sufficient period of time to allow the supercritical fluid to dissolve into the biodegradable polymer with the help of the solvent; and (c) venting the supercritical fluid and the solvent by reducing the pressure in the chamber, thereby obtaining a porous biodegradable polymer.

Method of making porous biodegradable polymers

The present invention relates to crosslinking of porous materials made of biodegradable polymers. The method comprises: (a) placing a porous biodegradable polymer in a chamber; (b) introducing a supercritical fluid containing a crosslinking agent into the chamber to effect crosslinking of the porous biodegradable polymer; and optionally (c) introducing a pure supercritical into the chamber to wash the crosslinked polymer until the crosslinking agent is substantially removed from the polymer.

Method for crosslinking porous biodegradable polymers

The present invention discloses a method for preparing a hydrophilic porous polymeric material comprising the step of mixing a hydrophilic polymeric material with a hydrophobic material; solvent sintering the surface of the hydrophilic polymeric material with water or an aqueous solution; and removing the hydrophobic material contained within the hydrophilic polymeric material with a massive organic solvent. Thus, the hydrophilic porous polymeric material with high porosity and stable structure is rapidly mass produced.

Method for preparing hydrophilic porous polymeric materials

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Taipei, Taiwan

Yuan-Chia Chang