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Yu Zhou

Bal Ram Singh

This application is based, inter alia, on the discovery of a binding interaction between the Hn-33 hemagglutinin polypeptide of the type Aneurotoxin complex and synaptosomal proteins, including synaptotagmin II (Syt II). Methods of screening for compounds that modulate, e.g., increase or decrease, this interaction are provided. Also provided are compositions and methods for targeting compounds to neuronal and cancer cells by coupling the compounds to Hn-33 or biologically active Hn-33 variants.

Methods of identifying a compound that increases or decreases the interaction of Hn-33 with synaptotagmin II

A process for synthesizing metal borohydride especially sodium borohydride directly from borax by the use of proton H at room temperature and pressure. Said process comprising the steps of: Providing proton H by the use of metals or alloys that can form hydrides with hydrogen. In this case, the metals or alloys are the carriers of proton H Proton H also can be provided from hydrogen gas by the use of catalysts located on the surface of carriers. Making the proton H enters the lattice of boron oxides Removing the oxygen from the lattice of boron oxides by the use of the carriers.

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New Bedford, MA, United States of America

Yu Zhou