Rutgers, the State University of New Jersey

Yu Zhang

Richard H Ebright

Yon W Ebright

David Degen

Yu Feng

The invention provides bipartite inhibitors of bacterial RNA polymerase having the general structural formula (I):X-&#x3b1;-Y&#x2003;&#x2003;(I)wherein X is an moiety that binds to the rifamycin binding site of a bacterial RNA polymerase, Y is a moiety that binds to the GE23077 binding site of a bacterial RNA polymerase, and &#x3b1; is a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.

Bipartite inhibitors of bacterial RNA polymerase

The invention provides bipartite inhibitors of bacterial RNA polymerase having the general structural formula (I): X-&#x3b1;-Y (I) wherein X is an moiety that binds to the rifamycin binding site of a bacterial RNA polymerase, Y is a moiety that binds to the GE23077 binding site of a bacterial RNA polymerase, and is a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.

The invention provides compounds of formula (I):X-&#x3b1;-Y&#x2003;&#x2003;(I)wherein X, Y, and a have any of the values defined in the specification and salts thereof. The compounds are inhibitors of bacterial RNA polymerase.

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New Brunswick, NJ, United States of America

Yu Zhang