Sirna Therapeutics, Inc.

Merck Sharp + Dohme Corp.

University of Central Florida Research Foundation, Inc.

Sima Therapeutics, Inc.

Yu Yuan

Vasant R Jadhav

Steven L Colletti

Francis Gosselin

Anthony W Shaw

David M Tellers

Thomas Joseph Tucker

Weimin Wang

Vadim Y Dudkin

Rubina G Parmar

Lu Tian

Kathleen B Calati

Marina Busuek

Robert A Kowtoniuk

Rachel Anne Storr

Aaron Momose

Jeffrey Aaronson

Hongbiao Liao

Tao Pei

Quang Truong

Craig Parish

Stanley F Barnett

Daniel Zewge

Lijun Wang

Man Zhu

Norihiro Ikemoto

Jeffrey G Aaronson

René Bartz

Aaron A Momose

Vadim Dudkin

Guang Huang

Claribel Murillo Solano

Rene Bartz

Antimalarial compounds of the formula: in which n is 1 or 2; X is C or N; Ris a moiety comprising a secondary amine and a tertiary amine joined by a Cto Calkyl chain; and Ris CF, F, or H, or an analog, combination, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof. Pharmaceutical compounds including the antimalarial compounds. Methods of treating or preventing malaria comprising administering an effective amount of the antimalarial compounds.

Antimalarial compounds

Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides

Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

Tetragalnac containing conjugates and methods for delivery of oligonucleotides

In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3' and/or 5&#x2032; end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.

Single chemical entities and methods for delivery of oligonucleotides

Growing community of inventors

Orlando, FL, United States of America

Yu Yuan