International Business Machines Corporation

Lemon Inc.

State Grid Corporation of China

Tasly Pharmaceutical Group Co., Ltd.

Asymchem Laboratories (tianjin) Co., Ltd.

Asymchem Life Science (tianjin) Co., Ltd

State Grid Tianjin Electric Power Company

Jiangsu Tasly Diyi Pharmaceutical Co., Ltd.

Shangai Wiscom Sunest Electric Power Technology Co., Ltd.

Electric Power Science & Research Institute of State Grid Tianjin Electric Power

Yu Xuan Zhang

Yuheng Zhang

Xiao Feng Guan

JiuFu Guo

Rui Li

Jiangping Lu

Hao Hong

Na Zhang

Kejian Zhang

Xuecheng Jiao

Bin Liu

Deepak Srinivas Turaga

Daby Mousse Sow

Jun Guo

Guocheng Wang

Zheng Chen

Gage James

Yi Ding

Mingxia Wang

Jiu Fu Guo

Xudong Wang

Hongyu Xiong

Han Wang

Yiqi Feng

Yuan Gao

Xianxu Huo

Yan Qi

Guodong Li

James Gage

Ke Xu

Qingyi Lu

Xiangyu Zeng

Yiming Yang

Yuying Liu

Wenzheng Liu

Qingwei Hou

Jiying Yang

Pan Zhang

Jingyan Han

Yuzhe Gao

Ning Jiang

Yihan Yang

Tianyu Zhang

Haibiao Wang

Hailong Yang

Zi Xuan Wu

Ping Tang

Yanjun Wen

Qiuliang Jiao

Wangxi Xue

Chao Huang

Qinghu Hu

The present application relates to the technical field of genetic engineering, and provides a monooxygenase mutant, a preparation method and application thereof. The monooxygenase mutant has any one of the amino acid sequences shown in (I) and (II): (I) an amino acid sequence having at least 80% identity with the amino acid sequence shown in SEQ ID NO. 1; and (II) an amino acid sequence obtained by modifying, substituting, deleting, or adding one or several amino acids to the amino acids at 23 to 508 positions of the amino acid sequence shown in SEQ ID NO. 1, the substituting referring to a substitution of 1 to 34 amino acids, wherein the mutant has the activity of monooxygenase.

Monooxygenase mutant, preparation method and application thereof

There are provided methods, devices, and computer program products for similarity determination. In a method, first and second access data are obtained for a first and a second group of users who access a first and a second website, respectively. A first and a second jump path are generated for the first and second groups of users based on the first and second access data, respectively. The first and second jump paths describe access history for the first and second groups of users among webpages in the first and second websites, respectively. A similarity is determined between the first and second websites based on the first and second jump paths. Here, access data are used for similarity determination and unvisited webpages are not considered in the similarity determination. Therefore, the computation workload may be lowered, and the noise caused by the unvisited webpages may be reduced.

Website similarity determination

Provided is an amino acid dehydrogenase mutant. The amino acid sequence of the mutant is obtained by mutating the amino acid sequence shown in SEQ ID NO:1. The mutation includes at least one of the following mutation sites: 64th, 94th, 133rd, 137th, 148th, 168th, 173rd, 183 rd, 191st, 207th, 229th, 248th, 255th and 282nd sites; or the amino acid sequence of the amino acid dehydrogenase mutant is an amino acid sequence having the mutation sites in the mutated amino acid sequence and having a 80% or more homology with the mutated amino acid sequence. The mutant enzyme activity is more than 50 times higher than that of wild amino acid dehydrogenase, and the enzyme specificity is also correspondingly improved.

Amino acid dehydrogenase mutant and use thereof

Disclosed are a distribution transformer terminal and a method for monitoring a state of a distribution transformer court device. The distribution transformer terminal includes an ARM core processor, a carrier communication module connected to a court device, a sub-G wireless communication module connected to the court device and a GPS module connected to the court device. The ARM core processor is connected to the carrier communication module, the sub-G wireless communication module and the GPS module. The ARM core processor is configured to identify a phase of the court device and a court to which the court device belongs, acquire an operating state and fault information of the court device through the sub-G wireless communication module, and acquire geographical location information of the court device through the GPS module.

Distribution transformer terminal and method for monitoring a state of a distribution transformer court device

An embodiment of the invention may include a method, computer program product and system for multi-threaded programming. An embodiment may include creating a plurality of threads. Each of the plurality of threads implements a same functionality. An embodiment may include determining a first operation implementing the functionality using a first group of resources. An embodiment may include determining at least one second operation implementing the functionality using at least one second group of resources. An embodiment may include enabling each thread of the plurality of threads to call the first operation or the at least one second operation.

Multi-threaded programming

The disclosure provides a method for detection of an uninitialized variable. The method includes running a first function, wherein the first function comprises a local variable and a first flag associated with the local variable for indicating an initialization state of the local variable; calling a second function from the first function, with the local variable as a parameter of the second function, wherein the second function comprises a second flag associated with the parameter for indicating an initialization state of the parameter; and updating the first flag based at least on the second flag returned from the second function.

Runtime detection of uninitialized variable across functions

Provided in the present invention are a new method for preparing the crystalline forms of Temozolomide and three types of crystalline form of Temozolomide by the method. Said method comprises the following steps: a Temozolomide is dissolved into dimethyl sulphoxide, a second organic solvent is added for recrystallization to prepare the crystalline forms of Temozolomide, wherein the second organic solvent is an alcohol, a ketone, a halohydrocarbon or an ester.

Crystalline forms of temozolomide and the method for preparing same

A method of meta-learning includes receiving a prediction objective, extracting a plurality of subsets of data from a distributed dataset, generating a plurality of local predictions, wherein each local prediction is based on a different subset of the plurality of subsets of data and the prediction objective, combining the plurality of local predictions, and generating a final prediction based on the combined local predictions.

Scalable online hierarchical meta-learning

The present invention relates to a new use of traditional Chinese drug products of Danshensu (DLA), Notoginsenoside R1 (R1) and their combination, in particular to the therapeutic and preventive effects of DLA, R1 and their combination on the diseases caused by microcirculation disorder.

Use of Danshensu, Notoginsenoside R1 or their combination in preparation of medicaments for preventing and treating diseases caused by microcirculation disorder

Growing community of inventors

Shanghai, China

Yu Xuan Zhang