Medshine Discovery Inc.

Shijiazhuang Sagacity New Drug Development Company, Ltd.

Wuxi Biocity Biopharmaceutics Co., Ltd.

Yu Xu

Yunfu Luo

Maoyi Lei

Shuhui Chen

Junmiao Li

Guoli Zhang

Jinghong Dong

Jian Li

Ran Wei

A compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and disclosed is an application thereof in the preparation of a medication for treating diseases related to a CRBN receptor.

Bicyclic compound that acts as CRBN protein regulator

Disclosed are a crystal form of 1H-imidazo[4,5-b]pyridine-2(3H)-one compound and a preparation process therefor, and use of the crystal form in the manufacture of a medicament for treating a disease associated with PDE4 receptor. 

Crystal form of 1H-imidazo[4,5-b]pyridine-2(3H)-one compound and preparation process therefor

Disclosed are a series of pyrimidine sulfamide compounds and applications thereof in preparing a drug for a disease related to an ETreceptor antagonist. In particular, disclosed is a derived compound represented by formula (I) or a tautomer or pharmaceutically acceptable composition thereof. 

Pyrimidine sulfamide derivative and preparation method and medical application thereof

Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof. 

Tricyclic furan-substituted piperidinedione compound

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Shanghai, China

Yu Xu