Km Biologics Co., Ltd.

Sap Se

Kumamoto University

Telefonaktiebolaget Lm Ericsson (publ)

National University Corporation Kumamoto University

Yu Su

Christoph Weyerhaeuser

Boris Gruschko

Mingquan Bao

Toshihiro Nakashima

Kenji Soejima

Masaharu Torikai

Hirofumi Jono

Yukio Ando

Masayo Ueno

Tomoyo Takeo

Akihiko Hosoi

Mineyuki Mizuguchi

Christian Mohr

Martin Strenge

Helmut Prestel

Reiner Singer

Sebastian Seifert

Rolf Hammer

Kai Baumgarten

Hirofumi Higuchi

Sigrid K Wortmann

Philipp Grosse

Veit Spaegele

Thomas Elvers

Junhui Liu

Juan Ge

Jianfeng Yan

A human antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The human antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a human antibody suitable for application to human body.

Anti-transthyretin human antibody

A humanized antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The humanized antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a humanized antibody suitable for application to human body.

Anti-transthyretin humanized antibody

Methods and apparatus, including computer program products, are provided for implementing a cooperative model between an application and a database. In one aspect, there is provided a computer-implemented method. The method may include receiving from an application a command to perform an operation at a database; accessing metadata representative of the application; configuring, based on at least the metadata, a result of the operation; and sending the configured result to shared memory accessible by the application. Related apparatus, systems, methods, and articles are also described.

Cooperative model between an application server and a database

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Shanghai, China

Yu Su