Ubix Therapeutics, Inc.

Yu Ri Choi

Ji Young Kim

Song Hee Lee

Je Ho Ryu

Ho Hyun Lee

Jung Min Ahn

Ji Youn Park

Mi Young Jang

Yae Jin Woo

Hanwool Kim

The present disclosure provides a substituted piperidine compound of Chemical Formula 1, wherein X is CR, or a pharmaceutically acceptable salt thereof having activity of degrading androgen receptor (AR). The present disclosure also provides a composition comprising such a substituted piperidine compound or a pharmaceutically acceptable salt thereof. The present disclosure also provides a medical use of a substituted piperidine compound according to the present disclosure, a salt thereof, and a composition comprising the same for the treatment or prophylaxis of AR-related diseases. The present disclosure also provides a method for treating or preventing an AR-related disease comprising administering to a subject in need thereof an effective amount of a substituted piperidine compound according to the present disclosure, a salt thereof, or a composition comprising the same.

Substituted piperidines for androgen receptor degradation

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Incheon, South Korea

Yu Ri Choi