Toray Industries, Inc.

Tokyo Medical and Dental University

Tokai University Educational System

Tokai University

Toray University Educational System

Yu Nagase

Kazuhiko Ishihara

Yasuhiko Iwasaki

Toru Arakane

Motonori Hochi

Yuki Sekido

Yosuke Okamura

Naoya Shimoyamada

Masataka Oku

Takuya Komachi

A polymer laminate has 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm that are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. A polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.

Polymer laminate

Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer. 

Diamine compound having phosphorylcholine group, polymer thereof, and process for producing the polymer

A compound of the invention is a specific compound having a phosphorylcholine group, and a polymer of the invention comprises at least 1 mol % of repeating units with a phosphorylcholine group and has a number-average molecular weight of 1,000 or more, the repeating units with a phosphorylcholine group being represented by the formula (II): wherein A is a bond selected from a single bond, &#x2014;O&#x2014;, &#x2014;COO&#x2014;, &#x2014;OOC&#x2014;, &#x2014;CONH&#x2014;, &#x2014;NH&#x2014;, &#x2014;NHCO&#x2014;, &#x2014;NR&#x2014; and &#x2014;CHO&#x2014; where Ris an alkyl group having 1 to 6 carbon atoms; and m is an integer of 1 to 12.

Compound having phosphorylcholine group, polymer thereof and process for producing the same

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Hiratsuka, Japan

Yu Nagase