National Cheng-Kung University

Yu-Min Kuo

Gwo Giun Lee

Gwo-Giun Lee

Nan-Shan Chang

Meng-Ru Tsai

Tzu-Cheng Chao

Te-Han Kung

Yi-Ru Xie

A system and a method for Alzheimer's disease prediction using a neural network, a computer-readable recording medium with a stored program, and a computer program product are provided. The processor obtains a first brain MRI data, a second brain MRI data, a first neuropsychological assessment score, and a second neuropsychological assessment score. The processor obtains a plurality of image feature data according to the first brain MRI data and the second brain MRI data. Each image feature data is selected from a group consisting of a plurality of hippocampal subfield geometric change data. The processor obtains a neuropsychological change data according to the first neuropsychological assessment score and the second neuropsychological assessment score. The processor obtains an Alzheimer's disease prediction result according to the neural network module, the image feature data, and the neuropsychological change data.

System and method for Alzheimer's disease prediction using neural network, computer-readable recording medium with stored program, and computer program product

The present disclosure relates to a method for providing biomarker for early detection of Alzheimer's Disease (AD), and particularly to a method that is able to enhance the accuracy of predicting AD from Mild Cognitive Impairment (MCI) patients using the Hippocampus magnetic resonance imaging (MRI) scans and Mini-Mental State Examination (MMSE) data. The providing MRI images containing the anatomical structure of Hippocampus biomarker and MMSE data as a training data set; training a processor using the training data set, and the training comprising acts of receiving MRI images and MMSE data as a testing data set from a target; and classifying the test data by the trained processor to include aggregating predictions.

Biomarker for early detection of alzheimer disease

A method for treating Alzheimer's disease and a method for downregulating protein aggregation in brain are disclosed, which respectively comprises: administering a zinc finger-like peptide to a subject in need thereof, wherein the zinc finger-like peptide comprises an amino acid sequence of RRSSSCK (SEQ ID NO: 1).

Method for treating Alzheimer's disease and method for downregulating protein aggregation in brain

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Tainan, Taiwan

Yu-Min Kuo