The University of Tokyo

Tokyo Medical and Dental University

Nippon Steel Corporation

Nanocarrier Co., Ltd.

Yu Matsumoto

Kazunori Kataoka

Nobuhiro Nishiyama

Kanjiro Miyata

Takehiko Ishii

Takanori Yokota

Kazutaka Nishina

Hidehiro Mizusawa

Yasutaka Anraku

Yu Fukusato

Akihiro Mizoguchi

Hiroya Kuwahara

Shigeru Hashimoto

Yasuki Kato

Shigeto Fukushima

Takahiro Nomoto

Koichi Nishizawa

Ronald James Christie

[Object] What is provided is a manufacturing method of a galvannealed steel sheet capable of further promoting alloying of zinc plating with the steel sheet. [Resolution Means] A manufacturing method of a galvannealed steel sheet, including: forming on a surface of a steel sheet after hot rolling and pickling which contains, by mass %, C: 0.001% to 0.350%, Si: 0.001% to 2.500% or P: 0.001% to 0.100%, or combination thereof, Mn: 0.10% to 3.00%, S: 0.001% to 0.010%, N: 0.0010% to 0.0065%, and sol. Al: 0.001% to 0.800% with a remainder being Fe and impurities, grooves having an opening surface width of 10 &#x3bc;m to 25 &#x3bc;m and a depth of 10 &#x3bc;m to 30 &#x3bc;m at intervals of 20 &#x3bc;m to 500 &#x3bc;m; cold rolling the steel sheet at a rolling reduction of 30% or more; reduction annealing the steel sheet after the cold rolling; immersing the steel sheet in a hot-dip galvanizing bath containing 0.10 mass % to 0.20 mass % of Al with a remainder consisting of Zn and optional components, and adhering a hot-dip galvanized layer to the surface of the steel sheet; and heating the steel sheet to which the hot-dip galvanized layer is adhered, and alloying the steel sheet with the hot-dip galvanized layer.

Manufacturing method of galvannealed steel sheet

The present invention provides a vesicle, a conjugate, a composition comprising the vesicle or the conjugate, for use in delivering a drug to the brain, and a method for administering the same. The composition of the present invention is a composition for administration to a subject according to a dosing regimen, comprising a carrier for drug delivery, wherein the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject, and the carrier is modified at the outer surface thereof with a GLUT1 ligand.

Carrier for use in delivering drug, conjugate, composition comprising same, and method for administrating same

A composition of matter for use in encapsulating a drug is expressed by formula (1) or formula (2): wherein Rand Rare each independently a hydrogen atom or a substituted or unsubstituted, linear or branched alkyl group having 1 to 12 carbon atoms; A is a hydrophilic polymer chain; Land Lare each a linking group; B is a cation-containing group; Ris a side chain of an amino acid; z is an integer of 5 to 500; x is an integer of 40% or more of z; y is 0 or a positive integer; z-x-y is 0 or a positive integer; p is an integer of 1 to 10; and q is an integer of 1 to 10.

Particle composition and pharmaceutical composition using particle composition

Growing community of inventors

Tokyo, Japan

Yu Matsumoto