Microsoft Technology Licensing, LLC

Columbia University

The Rockefeller University

Memorial Sloan Kettering Cancer Center

Yu Lin Chen

Jin Li

Aaron William Ogus

Cheng Huang

Douglas Wayne Phillips

Jinyang Li

Shuai Mu

Yannis Tsividis

Sanford M Simon

Thomas Wiesner

Ping Chi

In various embodiments, methods and systems for implementing distributed data object management are provided. The distributed data object management system includes a distributed storage system having a local metadata-consensus information store in and one or more remote metadata-consensus information stores. A metadata-consensus information store is configured to store metadata-consensus information. The metadata-consensus information corresponds to erasure coded fragments of a data object and instruct on how to manage the erasure coded fragments. The distributed storage system further includes a local data store and one or more remote data stores for the erasure coded fragments. The distributed data object management system includes a distributed data object manager for operations including, interface operations, configuration operations, write operations, read operations, delete operations, garbage collection operations and failure recovery operations. The distributed data object management system is operates based on metadata paths and data paths, operating in parallel, for write operations and read operations.

Distributed data object management system

In various embodiments, methods and systems for implementing distributed data object management are provided. The distributed data object management system includes a local metadata-consensus information store and one or more remote metadata-consensus information stores for metadata-consensus information and a local data store and one or more remote data stores for erasure coded fragments. For a write operation, corresponding metadata writes and data writes are performed in parallel using a metadata write path and a data write path, respectively, when writing to the local metadata-consensus information store and the one or more remote metadata-consensus information stores and the local data store and the one or more remote data stores. And, for a read operation, corresponding metadata reads and data reads are performed in parallel using a metadata read path and a data read path, respectively, when reading from the metadata-consensus information stores and the data stores.

Distributed data object management system operations

The present invention relates to a Truncated isoform of Anaplastic Lymphoma Kinase ('TALK'). Expression of this isoform is associated with malignancy and with responsiveness to ALK inhibitors. Detection of the isoform may be used in diagnostic and therapeutic methods. Because it arises as a result of variant transcription rather than genetic rearrangement, its presence would be undetected by genomic testing.

Isoform of anaplastic lymphoma kinase and its uses

Continuous-time digital systems implemented with separate timing paths and data paths are disclosed. The disclosed continuous-time digital systems, can implement an event-grouping and detection method that can be used feedback systems with propagation delays. By implementing event-detection into a feedback loop of a continuous-time digital system, the system can automatically stop when there is no event in the system. When new events are detected the system can commence operation.

Methods and systems for event-driven recursive continuous-time digital signal processing

Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is present.

Animals, cells and methods for production of detectably-labeled antibodies

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New York, NY, United States of America

Yu Lin Chen