Gc Cell Corporation

Mogam Biotechnology Research Institute

Mogam Institute for Biomedical Research

Mogam Biotechnology Institute

Green Cross Labcell

Yu Kyeong Hwang

Bitna Yang

Hyun Ah Kim

Bokyung Min

Hyojin Kim

Sungyoo Cho

Hyejin Chung

Eun Sol Lee

Han Sol Kim

Eun Ji Kim

Gyeong-min Park

Yusun Kim

Gyeong Min Park

Su Hyun Gwon

Mi Young Jung

Jung Hyun Her

Sung Yong Won

Sung Yoo Cho

Bo Kyung Min

Hana Choi

Okjae Lim

Eun-Kyoung Lee

Sangmi Kang

Ho Yong Lim

The present invention provides a chimeric antigen receptor and natural killer cells expressing the same, and particularly, a chimeric antigen receptor (CAR) which includes an intracellular signaling domain including the whole or a portion of an OX40 ligand (CD252), thereby having excellent effects of increasing anticancer activity of immune cells, and immune cells expressing the same.

Chimeric antigen receptor and natural killer cells expressing same

The present invention relates to a method for culturing cord blood-derived natural killer cells using transformed T cells. The method of the present invention uses transformed T cells to culture natural killer cells and enables effective proliferation and production of natural killer cells from a small amount of seed cells. In addition, natural killer cells produced by the method of the present invention have improved cytotoxicity. Therefore, the method of the present invention is useful in commercializing natural killer cells for cell therapy. Furthermore, natural killer cells produced by the method of the present invention are useful for cell therapy.

Method for culturing cord blood-derived natural killer cells using transformed T-cells

A method for culturing natural killer cells uses genetically modified T cells. The method for culturing natural killer cells, using genetically modified T cells enables the effective proliferation and production of natural killer cells from a smaller amount of source cells. In addition, the method enhances the cytolytic activity of natural killer cells. Therefore, the method for culturing natural killer cells, using genetically modified T cells may be suitable for various applications in commercializing cell therapy products. Further, the natural killer cells produced by the culturing method can be useful as a cell therapy product.

Method for culturing natural killer cell, using transformed T cell

The present invention relates to a method for producing natural killer cells using T cells, and more particularly, to a method for producing natural killer cells, which comprises culturing seed cells using CD4(+) T cells as feeder cells. The method for producing natural killer cells using T cells according to the present invention is a method capable of producing natural killer cells by selectively proliferating only natural killer cells from a small amount of seed cells while maintaining the high killing activity of the natural killer cells. The method of the present invention can produce a large amount of natural killer cells that can be frozen, and thus is useful for commercialization of cell therapeutic agents.

Method for culturing natural killer cells using T cells

The present invention relates to a method for producing natural killer cells (hereinafter, referred to as 'NK cells'), NK cells produced thereby, and a composition for treating cancers and infectious diseases containing the same. The present invention provides a method for producing NK cells, which maintain high cytotoxicity and cell viability to exhibit high therapeutic effects against cancers and infectious diseases and can be cultured ex vivo at high efficiency and high concentration. In addition, a culture method which maintains cell concentration at a constant level is used for the production of NK cells, and thus the overgrowth of the cells can be prevented so that the cells can be maintained at an optimal state. Particularly, even when the cells are thawed after freezing, the function of the cells is not impaired, and the NK cells can maintain high cell viability and cytotoxicity. Thus, the NK cells can be easily stored and supplied in a liquid or frozen state without needing an additional treatment process.

Method for producing natural killer cells, natural killer cells produced thereby, and composition for treating cancers and infectious diseases containing the same

There are provided a polynucleotide encoding HCV epitopes, an immunogenic composition including same, and a method of inducing an HCV-specific immune response using same.

Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same

Growing community of inventors

Yongin-si, South Korea

Yu Kyeong Hwang