The University of Tokyo

Yu Kushida

Tetsuo Nagano

Kenjiro Hanaoka

Takahiro Egawa

Yuichiro Koide

Takuya Myochin

Koji Numasawa

Wen Piao

[Problem] To provide: a compound resulting from substituting with a silicon atom the oxygen atom at position 10 of a xanthene ring site of a rhodamine of which amino groups at position 3 and position 6 have an asymmetrical structure; a method for producing the compound; and a fluorescent probe that uses the compound. [Solution] The compound represented by general formula (I) or a salt thereof. 

Asymmetrical Si rhodamine and rhodol synthesis

A compound represented by the formula (I) (Rrepresents a substituent on the benzene ring; Rrepresents a monovalent substituent; Rand Rrepresent hydrogen atom, or an alkyl group; Rand Rrepresent an alkyl group, or an aryl group; Rand Rrepresent hydrogen atom, or an alkyl group; Rand Rrepresent hydrogen atom, or a monovalent substituent; and X represents silicon atom, germanium atom, or tin atom), or a salt thereof. 

Fluorescent probe

Growing community of inventors

Tokyo, Japan

Yu Kushida