Taipei Medical University

Yu-Jia Chang

Yuan-Soon Ho

Chia-Hwa Lee

Ching-Shyang Chen

Li-Ching Chen

Po-Li Wei

Ching-Shui Huang

Chih-Hsiung Wu

Shih-Hsin Tu

Ying-Jan Wang

Ko-Jiunn Liu

Neng-Yao Shih

Yu-Ching Lee

Yi-Yuan Yang

Sy-Jye Leu

I-Jen Huang

Hui-Wen Chang

Chien-Hsi Chang

Yung-Leun Shih

Bor-Yu Tsai

Ya-Chieh Chang

Ka-Wai Tam

Tzu-Chun Cheng

Jan-Show Chu

The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or &#x3b1;9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that &#x3b1;9-nAChR has an activating protein 1 (AP1)-binding site, that the &#x3b1;9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the &#x3b1;9-nAChR promoter at the AP1-binding site, indicating that ER-induced &#x3b1;9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.

Method of identifying a candidate compound which may inhibit &#x3b1;9-nAchR overexpression or estrogen receptor-dependent transcription in nicotine-derived-compound-induced breast cancer cells

The invention relates to antibodies against &#x3b1;-enolase I, their pharmaceutical compositions and diagnosis and treatment uses. Particularly, the invention provides polyclonal anti-&#x3b1;-enolase I antibodies and monoclonal single-chain variable fragment (scFv) anti-&#x3b1;-enolase antibodies, pharmaceutical compositions containing the same and their uses in uses in diagnosis and treatment of cancers, autoimmune disorders, ischemia and bacterial infection.

Anti-&#x3b1;-enolase I antibodies for diagnosis and treatment of &#x3b1;-enolase I-associated diseases

The invention found that overexpression and activation of &#x3b1;9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of &#x3b1;9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of &#x3b1;9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer.

Small interfering RNAs and methods for prevention, inhibition and/or treatment of malignant progression of breast cancer

Growing community of inventors

Taipei, Taiwan

Yu-Jia Chang