Regeneron Pharmaceuticals, Inc.

Regeneran Pharmaceuticals, Inc.

Yu Huang

William C Olson

Robert Babb

Dimitris Skokos

Xiaobin Xu

Bei Wang

Drew Dudgeon

Matthew Sleeman

Rosalynn Molden

Haibo Qiu

Mengqi Hu

Methods of predicting an in vivo serum concentration of an antibody with a post-translational modification of interest after administration of the antibody are provided, as are methods for predicting a subject's exposure to post-translational variants of the antibody. The methods include predicting a percentage of the antibody with the post-translational modification of interest using an in vivo rate constant determined for the post-translational modification, and multiplying the predicted percentage of the antibody with the post-translational modification of interest by the in vivo concentration of the antibody to determine the concentration of the antibody with the post-translational modification of interest.

Quantitation and modeling of quality attributes of therapeutic monoclonal antibodies

Provided herein are antibodies, and antigen-binding fragments thereof that specifically bind glucocorticoid-induced tumor necrosis factor receptor (GITR), compositions comprising the antibodies or antigen-binding fragments thereof, and methods of using the same, including, e.g., methods of treatment using the same.

Therapeutic uses of anti-GITR antibodies

The present disclosure generally pertains to methods of identifying and quantitating host cell proteins (HCPs) in therapeutic protein development. In particular, the present invention generally pertains to methods of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for unbiased identification and sensitive quantitation of HCPs in therapeutic protein development.

Unbiased and high-throughput identification and quantification of host cell protein impurities by automated iterative LC-MS/MS (HCP-AIMS) for therapeutic protein development

Anti-GITR antibodies and uses thereof

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Ossining, NY, United States of America

Yu Huang